Establishing Functionally Segregated Dopaminergic Circuits

Medicine, Psychiatry, Neurology, Life Sciences, Cell Biology,
dopaminergic circuits   functional segregation   neuronal development   molecular mechanisms   neuropsychiatric disorders  

Functional Segregation of Dopaminergic Neural Circuits and Their Developmental Mechanisms Academic Background Dopamine is a crucial neurotransmitter in the brain, regulating various physiological functions, including motor control, emotional regulation, motivation, learning, and memory. Dopaminergic neurons are primarily located in the midbrain, an...

Antisense Oligonucleotide–Mediated MSH3 Suppression Reduces Somatic CAG Repeat Expansion in Huntington’s Disease iPSC–Derived Striatal Neurons

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
Huntington's disease   CAG repeat expansion   antisense oligonucleotide   iPSC-derived neurons   MSH3 protein  

Therapeutic Potential of ASO-Mediated MSH3 Suppression in Huntington’s Disease Academic Background Huntington’s disease (HD) is a neurodegenerative disorder caused by abnormal expansion of the CAG repeat sequence in the huntingtin gene (HTT). This expanded CAG repeat continues to expand somatically over time, driving the onset and progression of th...

Prior Vaccination Prevents Overactivation of Innate Immune Responses During COVID-19 Breakthrough Infection

Medicine, Infectious Diseases, Life Sciences, Cell Biology, Biochemistry, Immunology,
COVID-19   breakthrough infection   innate immune response   vaccination   sex-specific patterns  

How COVID-19 Vaccines Affect Immune Responses During Breakthrough Infections Background Introduction As the COVID-19 pandemic continues, an increasing number of infections are “breakthrough infections,” occurring in individuals who have been vaccinated or previously infected with SARS-CoV-2. Although vaccination has significantly reduced the risk o...

Intestinal Epithelium–Derived IL-34 Reprograms Macrophages to Mitigate Gastrointestinal Tract Graft-Versus-Host Disease

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Gastroenterology, Hematology, Life Sciences, Cell Biology, Immunology,
Graft-versus-host disease   Macrophages   IL-34   Intestinal epithelium   Immunomodulation  

Academic Report on the Role of Intestinal Epithelium-Derived IL-34 in Alleviating Graft-versus-Host Disease 1. Academic Background Graft-versus-Host Disease (GVHD) is a severe complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT), and gastrointestinal (GI) GVHD is the primary determinant of morbidity and mortality du...

Tumor Extracellular Vesicle–Derived PD-L1 Promotes T Cell Senescence Through Lipid Metabolism Reprogramming

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
tumor microenvironment   T cell senescence   lipid metabolism   PD-L1   immunotherapy  

PD-L1 in Tumor-Derived Extracellular Vesicles Promotes T Cell Senescence through Lipid Metabolism Reprogramming Academic Background In recent years, immunotherapy has shown great promise in cancer treatment, particularly in checkpoint blockade therapies targeting PD-1/PD-L1 (programmed cell death protein 1 and its ligand) and CTLA-4 (cytotoxic T-ly...

Triple Knockdown of CD11a, CD49d, and PSGL1 in T Cells Reduces CAR-T Cell Toxicity but Preserves Activity Against Solid Tumors in Mice

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
CAR-T cells   solid tumors   immunotherapy   cell adhesion   cell migration  

Study on Reducing Toxicity of CAR-T Cell Therapy for Solid Tumors Academic Background Chimeric antigen receptor T-cell (CAR-T) therapy has made significant progress in treating hematologic malignancies, but its application in solid tumors faces major challenges. Solid tumors often lack tumor-specific antigens (TSAs), and CAR-T cells may attack norm...