Unlocking Melanoma Suppression: Insights from Plasma-Induced Potent miRNAs through PI3K-AKT-ZEB1 Axis

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Non-thermal plasma   miRNA sequencing   Differential regulation   Melanoma inhibition   PI3K-AKT-ZEB1 axis  

Study on Melanoma Suppression by Non-Thermal Atmospheric Pressure Plasma via the PI3K-AKT-ZEB1 Axis Academic Background Melanoma is the most aggressive and deadly form of skin cancer, particularly in its advanced stages, making treatment extremely challenging. Although recent advancements in targeted therapy and immunotherapy have improved patient ...

Stochastic Modeling of Single-Cell Gene Expression Adaptation Reveals Non-Genomic Contribution to Evolution of Tumor Subclones

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
stochastic modeling   gene expression adaptation   tumor subclones   Wnt signaling   immunotherapy   non-genomic contribution   cellular evolution  

Stochastic Modeling of Single-Cell Gene Expression Adaptation Reveals Non-Genomic Contribution to Tumor Subclone Evolution Academic Background Cancer is a complex disease whose progression is driven by the evolution of cells that are selected through adaptive advantages for growth. Traditionally, cancer evolution research has focused primarily on g...

Contrastive Learning of T Cell Receptor Representations

Medicine, Life Sciences, Cell Biology, Biochemistry, Immunology,
T cell receptor   contrastive learning   sequence alignment   specificity prediction   language model  

New Breakthrough in T Cell Receptor (TCR) Specificity Prediction: The Introduction of the SCEPTR Model Academic Background T cell receptors (TCRs) play a crucial role in the immune system by determining the specificity of immune responses through their binding to peptide-MHC complexes (pMHCs). Understanding the interaction between TCRs and specific...

Study Reveals CDK2 Activity Crosstalk in ERK Kinase Translocation Reporter

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
ERK kinase   CDK2 activity   single-cell imaging   signaling pathway   computational methods  

CDK2 Activity Interference on ERK and p38 KTR Signals and Computational Correction Methods Recently, a paper published in Cell Systems by authors Timothy E. Hoffman, Chengzhe Tian, Varuna Nangia, and others revealed the interference of cyclin-dependent kinase 2 (CDK2) on the kinase translocation reporter (KTR) signals in the extracellular signal-re...

Multimodal Learning for Mapping Genotype–Phenotype Dynamics

Information Science, Computer Science, Artificial Intelligence, Medicine, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
multimodal learning   genotype-phenotype relationship   single-cell RNA sequencing   machine learning   cellular heterogeneity  

Multimodal Learning Reveals Genotype–Phenotype Dynamics Background The complex relationship between genotype and phenotype has long been a central question in biology. Genotype refers to the genetic information of an organism, while phenotype is the manifestation of this genetic information in a specific environment. Although Wilhelm Johannsen intr...

Mapping the Gene Space at Single-Cell Resolution with Gene Signal Pattern Analysis

Life Sciences, Cell Biology, Bioengineering, Genetics,
single-cell sequencing   gene embedding   graph signal processing   bioinformatics   gene co-expression  

Mapping the Gene Space at Single-Cell Resolution: A Study on Gene Signal Pattern Analysis (GSPA) Academic Background Single-cell RNA sequencing (scRNA-seq) technology has made significant progress in biological research in recent years, particularly in revealing the organizational structure of the cellular state space. However, although many comput...