The Role of Dysregulated miRNA-140 and miRNA-122 in Alzheimer's Disease

Medicine, Geriatrics, Neurology, Life Sciences, Biochemistry, Immunology,
Alzheimer's Disease   miRNA-140   miRNA-122   ADAM10   Cognitive Impairment   Neuroinflammation  

Analysis and Potential Applications of miRNAs Related to Alzheimer’s Disease Background and Research Motivation Alzheimer’s Disease (AD) is a progressively worsening neurodegenerative disorder and the most common form of dementia among the elderly. The pathological features of AD in the brain primarily include senile plaques formed by the accumulat...

Hyperglycemia Enhances Brain Susceptibility to Lipopolysaccharide-Induced Neuroinflammation via Astrocyte Reprogramming

Medicine, Endocrinology, Neurology, Life Sciences, Biochemistry,
hyperglycemia   neuroinflammation   astrocytes   microglia   lipopolysaccharide   RNA-sequencing   cognitive function  

Hyperglycemia Enhances Brain Susceptibility to Lipopolysaccharide-Induced Neuroinflammation via Astrocyte Reprogramming Academic Background Introduction Diabetes is a chronic metabolic disease affecting millions of people worldwide, characterized by hyperglycemia, or elevated blood glucose levels. For a long time, research has primarily focused on ...

Study on the Effects of Traumatic Brain Injury on Chronic Meningeal CLIP+ B Cells, Neuropathology, and Neurobehavioral Impairment in 5xFAD Mice

Medicine, Rheumatology and Immunology, Neurology, Medical Imaging, Life Sciences, Biochemistry, Immunology,
Traumatic Brain Injury   Alzheimer's Disease   B Cells   Neuropathology   Neurobehavioral Impairment   Immune Response   5xFAD Mice  

Research Report: Long-Term Effects of Class II Invariant Peptide (CLIP) Antagonism on CLIP+ B Cells in the Meninges, Neuropathology, and Neurobehavioral Deficits in 5xFAD Mice Research Background Traumatic brain injury (TBI) is a significant public health problem affecting millions of individuals worldwide each year. More importantly, TBI is a sign...

Microglial PDCD4 Deficiency Mitigates Neuroinflammation-Associated Depression via Facilitating Daxx Mediated PPARγ/IL-10 Signaling

Medicine, Infectious Diseases, Psychiatry, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Microglia   PDCD4   Neuroinflammation   Depression   PPARγ   IL-10  

Deletion of Microglia PDCD4 Alleviates Neuroinflammation-Associated Depression by Promoting DAXX-Mediated PPARγ/IL-10 Signaling Background In recent years, neuroinflammatory processes have been demonstrated to be associated with various psychiatric disorders, including schizophrenia, depression, and anxiety. A common feature of these diseases is th...

Single-Cell RNA Sequencing Reveals the Evolution of the Immune Landscape During Perihematomal Edema Progression After Intracerebral Hemorrhage

Medicine, Rheumatology and Immunology, Neurology, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
intracerebral hemorrhage   single cell RNA sequencing   perihematomal edema   immune cell   osteopontin  

Single-cell RNA Sequencing Reveals Evolution of Immune Landscape in Perihematomal Edema Post Hemorrhagic Stroke Research Background Intracerebral hemorrhage (ICH) is one of the global health threats, renowned for its high disability and mortality rates. Among the secondary brain injuries caused by ICH, the formation of perihematomal edema (PHE) is ...

Regulation of Neuroinflammation and Demyelination by Cystatin F Following Murine Coronavirus Infection of the Central Nervous System

Medicine, Infectious Diseases, Basic Medical Sciences, Neurology, Neurosurgery, Life Sciences, Biochemistry, Immunology,
Cystatin F   neuroinflammation   demyelination   murine coronavirus   central nervous system   immune response  

The Role of Cystatin F in Regulating Neuroinflammation and Demyelination in Spinal Cord Poliovirus Infection Background Knowledge Cystatin F is a secreted lysosomal cysteine protease inhibitor associated with every stage of virus-related neurological diseases, including host defense, demyelination, and myelination. However, research on how Cystatin...