Overexpression of REF-1 in Neovascular Eye Diseases and Its Inhibition by a Novel Compound

Medicine, Ophthalmology, Pharmacy, Oncology, Life Sciences, Biochemistry,
REF-1   neovascularization   eye disease   inflammation   redox   macular degeneration   carbonic anhydrase  

REF-1 Overexpression in Neovascular Eye Diseases and Therapeutic Targeting with a Novel Inhibitor Academic Background Neovascular age-related macular degeneration (nAMD) is a common blinding eye disease predominantly affecting individuals aged 60 years and older. nAMD is characterized by the formation of subretinal neovascularization, leading to re...

Demonstration of Femtosecond Laser Induced Refractive Index Change in Silk-Fibroin Hydrogels

Physics, Optics, Materials Science, Medicine, Ophthalmology, Life Sciences, Biochemistry, Bioengineering,
femtosecond laser   refractive index change   silk fibroin hydrogel   vision correction   biocompatibility   refractive errors   corneal implants  

Demonstration of Femtosecond Laser Induced Refractive Index Change in Silk-Fibroin Hydrogels: A New Hope for Future Ophthalmic Biocompatible Implants In today’s era of advanced biotechnology and rapid developments in the biomedical field, refractive correction techniques have become a global research hotspot in ophthalmology. However, current corre...

Spatial Multiomic Landscape of the Human Placenta at Molecular Resolution

Medicine, Obstetrics and Gynecology, Life Sciences, Cell Biology, Biochemistry, Immunology,
placenta   multiomics   molecular resolution   gene regulation   pregnancy complications  

A New Chapter in the Molecular Understanding of the Human Placenta: Breakthroughs in Spatial Multiomics Background and Research Questions The placenta is the first fetal organ to develop during human pregnancy and plays a critical role in ensuring successful gestation and healthy fetal development. Despite its importance, our understanding of the m...

Repurposing Large-Format Microarrays for Scalable Spatial Transcriptomics

Medicine, Life Sciences, Biochemistry, Immunology, Genetics,
spatial transcriptomics   microarrays   high-throughput   tissue analysis   gene expression   biomedical research   clinical pathology  

A New Method for Scalable Spatial Transcriptomics via Large-Format Microarrays: The Birth of Array-Seq Technology Background and Research Motivation In recent years, spatiomolecular analyses have become pivotal tools in biomedical research and clinical pathology due to their ability to study how the spatial organization of cells and molecules withi...

Efficient and Highly Amplified Imaging of Nucleic Acid Targets in Cellular and Histopathological Samples with PSABER

Medicine, Life Sciences, Cell Biology, Biochemistry, Genetics,
nucleic acid imaging   signal amplification   in situ hybridization   fluorescence microscopy   histopathology  

A New Platform for Efficient Signal Amplification of Nucleic Acid Targets in Tissue and Clinical Research: PSABER Background and Related Knowledge Since its first introduction by Pardue and Gall in the 1960s, in situ hybridization (ISH) has been widely adopted in research and clinical applications for its ability to spatially map nucleic acid targe...

Single-Molecule Dynamic Structural Biology with Vertically Arranged DNA on a Fluorescence Microscope

Chemistry, Nanoscience, Life Sciences, Biochemistry, Biophysics,
single-molecule fluorescence   DNA-protein interactions   graphene energy transfer   dynamic structural biology   super-resolution microscopy  

Single-Molecule Dynamic Structural Biology: Breakthrough in Observing DNA-Protein Interactions Using Graphene Background Introduction The intricate and precise interactions between DNA and proteins play a crucial role in fundamental biological functions such as DNA replication, transcription, and repair. However, observing these interaction process...