Multiscale Footprints Reveal the Organization of Cis-Regulatory Elements

Information Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
cis-regulatory elements   chromatin accessibility   transcription factors   deep learning   single-cell sequencing   genomics   cell differentiation  

Multiscale Footprints Reveal the Role of Cis-Regulatory Elements in Cell Differentiation and Aging Background Introduction The regulation of gene expression is a key mechanism in cell fate determination and disease development, and cis-regulatory elements (CREs) play a crucial role in this process. CREs dynamically regulate gene expression by bindi...

Rapid and Scalable Personalized ASO Screening in Patient-Derived Organoids

Medicine, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
personalized therapeutics   antisense oligonucleotides   rare diseases   organoid models   gene therapy   Duchenne muscular dystrophy   stem cells  

Establishment of a Personalized Antisense Oligonucleotide (ASO) Screening Platform Based on Patient-Derived Organoids Academic Background In recent years, with the rapid development of genome sequencing technologies, an increasing number of rare genetic diseases have been found to be associated with specific gene mutations. Antisense oligonucleotid...

Photothermal MXene-Embedded Tannin–Eu3+ Particles as In Situ Bacterial Vaccines for Accelerating Healing of Wounds Infected by Seawater Immersion and Providing Persistent Anti-Infection Effects

Chemistry, Nanoscience, Materials Science, Medicine, Infectious Diseases, Life Sciences, Biochemistry, Bioengineering, Immunology,
MXene   Tannin   Wound Healing   Anti-infection   In Situ Vaccine  

Photothermal MXene-Embedded Tannin-Eu³⁺ Particles as In Situ Bacterial Vaccines for Seawater-Immersed Infected Wounds Academic Background Seawater-immersed wounds are prone to severe infections due to the low temperature, high salinity, and bacteria-rich environment, which hinder wound healing. Traditional antibacterial strategies often fail to pro...

Cav3.3-Mediated Endochondral Ossification in a Three-Dimensional Bioprinted GelMA Hydrogel

Cav3.3-Mediated Endochondral Ossification in a Three-Dimensional Bioprinted GelMA Hydrogel

Medicine, Orthopedics, Life Sciences, Biochemistry, Bioengineering,
bone organoid   endochondral ossification   T-type voltage-dependent calcium channel   Cav3.3   3D bioprinting   GelMA hydrogel   chondrocyte differentiation  

Study on Cav3.3-Mediated Endochondral Ossification in 3D Bioprinted GelMA Hydrogel Research Background Bone development is a complex process, in which the growth plate (GP) plays a crucial role in the longitudinal growth of long bones. The growth plate regulates bone maturation through the process of endochondral ossification (EO). However, GP dysf...

Electrospun Polyvinyl Alcohol Fibres Incorporating an Antimicrobial Gel for Enzymatically Controlled Reactive Oxygen Species Release

Chemistry, Polymer Chemistry, Materials Science, Organic Polymeric Materials, Life Sciences, Biochemistry, Bioengineering, Microbiology,
antimicrobial   electrospinning   hydrogen peroxide   polyvinyl alcohol   reactive oxygen species   tissue engineering   wound dressing  

Study on Antimicrobial Gel Combined with Electrospun Polyvinyl Alcohol Fibers for Enzymatically Controlled Reactive Oxygen Species Release Academic Background The skin is the body’s first line of defense against infections, and the presence of wounds can compromise this barrier, increasing the risk of infection. With the rise of antibiotic resistan...

Multisite DNA Methylation Alterations of Peripheral Blood Mononuclear Cells Serve as Novel Biomarkers for the Diagnosis of AIS/Stage I Lung Adenocarcinoma: A Multicenter Cohort Study

Medicine, Respiratory System, Oncology, Life Sciences, Biochemistry, Genetics,
DNA methylation   early detection   lung adenocarcinoma   peripheral blood mononuclear cells   biomarkers   multicenter study   epigenetics  

Novel Early Diagnosis Method for Lung Adenocarcinoma Based on DNA Methylation in Peripheral Blood Mononuclear Cells Background Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related deaths worldwide, accounting for approximately 40% of lung cancer cases. Despite significant advancements in treatment, the prognosis of LUAD remains...