The Development and Application of an Engineered Direct Electron Transfer Enzyme for Continuous Levodopa Monitoring

Chemistry, Analytical Chemistry, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Biochemistry, Bioengineering,
levodopa   Parkinson's disease   direct electron transfer enzyme   biosensor   continuous monitoring  

Development of an Engineered Direct Electron Transfer Enzyme for Continuous Levodopa Monitoring Background Parkinson’s Disease (PD) is a chronic neurodegenerative disease that affects millions of people worldwide. It is characterized by the loss of dopaminergic neurons in the substantia nigra and the presence of α-synuclein aggregations forming Lew...

Advancements of Paper-Based Sensors for Antibiotic-Resistant Bacterial Species Identification

Chemistry, Nanoscience, Medicine, Infectious Diseases, Life Sciences, Biochemistry, Microbiology,
paper-based sensors   antibiotic resistance   bacterial infections   nanoparticles   detection techniques  

Advances in Paper-Based Sensors for the Detection of Antibiotic-Resistant Bacteria Background Antimicrobial resistance (AMR) is one of the most significant global public health challenges today. With the extensive use and misuse of antibiotics, more and more bacteria have developed resistance, rendering traditional treatments ineffective. According...

Resolving Native GABAA Receptor Structures from the Human Brain

Medicine, Neurology, Life Sciences, Biochemistry, Biophysics,
GABAA receptor   structural analysis   epilepsy   cryo-electron microscopy   drug binding   neurotransmitter   human brain  

Resolving Native GABAA Receptor Structures from the Human Brain: A Breakthrough Study Academic Background GABAA receptors (γ-aminobutyric acid type A receptors) are among the most important inhibitory neurotransmitter receptors in the brain, responsible for regulating fast inhibitory signaling in neurons. These receptors are not only key drug targe...

A Map of the Rubisco Biochemical Landscape

Life Sciences, Biochemistry, Bioengineering, Botany,
Rubisco   enzyme engineering   biochemical parameters   photosynthesis   CO2 fixation  

Research on the Functional Mapping of Rubisco Enzyme Background Introduction Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase) is the most abundant enzyme on Earth, responsible for the carbon dioxide fixation process in photosynthesis. However, Rubisco’s catalytic efficiency is low, and it is prone to side reactions with oxygen, limiting th...

Precise Modelling of Mitochondrial Diseases Using Optimized Mitobes

Medicine, Life Sciences, Cell Biology, Biochemistry, Genetics,
mitochondrial diseases   gene editing   Mitobes   mouse models   off-target effects   phenotypic evaluation   genetic mutations  

Precise Modeling of Mitochondrial Diseases: Research Based on Optimized Mitobes Academic Background Mitochondrial diseases are a group of genetic disorders caused by mutations in mitochondrial DNA (mtDNA), which affect cellular energy metabolism and lead to dysfunction in multiple organs. Mitochondrial DNA mutations can be homoplasmic (affecting al...

Multiscale Footprints Reveal the Organization of Cis-Regulatory Elements

Information Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
cis-regulatory elements   chromatin accessibility   transcription factors   deep learning   single-cell sequencing   genomics   cell differentiation  

Multiscale Footprints Reveal the Role of Cis-Regulatory Elements in Cell Differentiation and Aging Background Introduction The regulation of gene expression is a key mechanism in cell fate determination and disease development, and cis-regulatory elements (CREs) play a crucial role in this process. CREs dynamically regulate gene expression by bindi...