TDO2 Inhibition Counters Benzo[a]pyrene-Induced Immune Evasion and Suppresses Tumorigenesis in Lung Adenocarcinoma

Medicine, Oncology, Life Sciences, Biochemistry, Immunology,
Benzo[a]pyrene   TDO2   Immune evasion   Lung adenocarcinoma   Tryptophan metabolism   PD-L1   ICOSL  

The Role of TDO2 Inhibition in Lung Cancer Immune Evasion Background Introduction Lung cancer is one of the leading causes of cancer-related deaths worldwide, with smoking recognized as a primary cause of its occurrence. Cigarette smoke contains numerous carcinogens, among which benzo[a]pyrene (BAP), a polycyclic aromatic hydrocarbon, has been show...

Glutaminolysis is Associated with Mitochondrial Pathway Activation and Can Be Therapeutically Targeted in Glioblastoma

Medicine, Oncology, Life Sciences, Biochemistry,
Glioblastoma   Glutaminolysis   Mitochondria   Metabolic changes   Therapeutic target  

The Relationship Between Metabolic Reprogramming and Glutamine Metabolism in Glioblastoma Background Introduction Glioblastoma is a highly aggressive primary brain tumor with a very poor prognosis. Although current standard treatments include surgery, radiotherapy, and chemotherapy, there is no cure for the disease. In recent years, metabolic repro...

Complete Inhibition of Liver Acetyl-CoA Carboxylase Activity Exacerbates Liver Tumorigenesis in Mice Treated with Diethylnitrosamine

Medicine, Hepatobiliary System, Oncology, Life Sciences, Biochemistry,
liver cancer   de novo lipogenesis   acetyl-CoA carboxylase   tumorigenesis   diethylnitrosamine   metabolic pathway   mouse model  

Inhibition of Liver Acetyl-CoA Carboxylase (ACC) Activity Exacerbates Liver Tumorigenesis in Mice Academic Background Liver cancer is the sixth most common cancer globally and the third leading cause of cancer-related mortality. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. In recent years, the burden of liver canc...

GCN2-SLC7A11 Axis Coordinates Autophagy, Cell Cycle, and Apoptosis and Regulates Cell Growth in Retinoblastoma upon Arginine Deprivation

Medicine, Ophthalmology, Oncology, Life Sciences, Cell Biology, Biochemistry,
GCN2   SLC7A11   retinoblastoma   arginine deprivation   autophagy   cell cycle   apoptosis  

GCN2-SLC7A11 Axis Regulates Cell Growth and Survival in Retinoblastoma Under Arginine Deprivation Background Retinoblastoma (RB) is a common intraocular malignant tumor in children, accounting for 4% of all childhood cancers. Although current treatments such as chemotherapy are effective in some patients, they have drawbacks such as multidrug resis...

Unraveling Glycosphingolipid Metabolism in Neuroblastic Tumors Using Transcriptome-Weighted Network Analysis

Medicine, Oncology, Life Sciences, Biochemistry,
glycosphingolipid metabolism   neuroblastic tumors   GD2   reaction activity score   metabolic network   ganglioneuroma   ganglioneuroblastoma  

Transcriptome-Weighted Network Analysis of Glycosphingolipid Metabolism in Neuroblastoma Background Introduction Glycosphingolipids (GSLs) are a class of membrane lipids composed of a ceramide backbone linked to glycan moieties, widely present in the nervous system. They play crucial roles in cell signaling, cell-cell interactions, and tumorigenesi...

Real-Time Assessment of Relative Mitochondrial ATP Synthesis Response Against Inhibiting and Stimulating Substrates (MitoRaise)

Medicine, Oncology, Life Sciences, Biochemistry,
Relative mitochondrial ATP synthesis rate   Mitochondrial function   ATP   mtDNA copy number   MitoRaise  

Real-Time Assessment of Mitochondrial ATP Synthesis Response: MitoRaise Academic Background Mitochondria are the energy factories within cells, primarily synthesizing adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). ATP serves as the main energy carrier in cells, and its synthesis rate directly reflects the functional status...