Real-Time Assessment of Relative Mitochondrial ATP Synthesis Response Against Inhibiting and Stimulating Substrates (MitoRaise)

Medicine, Oncology, Life Sciences, Biochemistry,
Relative mitochondrial ATP synthesis rate   Mitochondrial function   ATP   mtDNA copy number   MitoRaise  

Real-Time Assessment of Mitochondrial ATP Synthesis Response: MitoRaise Academic Background Mitochondria are the energy factories within cells, primarily synthesizing adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). ATP serves as the main energy carrier in cells, and its synthesis rate directly reflects the functional status...

CYP19A1 Regulates Chemoresistance in Colorectal Cancer Through Modulation of Estrogen Biosynthesis and Mitochondrial Function

Medicine, Endocrinology, Gastroenterology, Oncology, Life Sciences, Biochemistry,
colorectal cancer   chemotherapy resistance   CYP19A1   mitochondria   mitochondrial respiratory chain complexes  

CYP19A1 Regulates Chemoresistance in Colorectal Cancer through Modulation of Estrogen Biosynthesis and Mitochondrial Function Background Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Despite significant advances in early detection and treatment strategies, chemoresistance remains a major obstacle to eff...

Rhof Promotes Snail1 Lactylation by Enhancing PKM2-Mediated Glycolysis to Induce Pancreatic Cancer Cell Endothelial–Mesenchymal Transition

Medicine, Oncology, Life Sciences, Biochemistry,
Pancreatic Cancer   Rhof   Endothelial–Mesenchymal Transition   Glycolysis   Snail1 Lactylation  

RhoF Promotes Snail1 Lactylation by Enhancing PKM2-Mediated Glycolysis to Induce Pancreatic Cancer Cell Endothelial–Mesenchymal Transition Academic Background Pancreatic cancer (PC) is a highly malignant tumor characterized by late diagnosis, strong invasiveness, and resistance to systemic therapy, leading to poor patient prognosis. Despite recent ...

Nonemissive Iridium(III) Solvent Complex as a Self-Reporting Photosensitizer for Monitoring Phototherapeutic Efficacy in a 'Signal On' Mode

Chemistry, Analytical Chemistry, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Biochemistry,
Iridium(III) solvent complex   Self-reporting photosensitizer   Phototherapeutic efficacy   Signal on   Immunogenic cell death  

Iridium(III) Solvent Complex as a Self-Reporting Photosensitizer for Monitoring Phototherapeutic Efficacy Academic Background Cancer is one of the leading causes of global mortality, significantly impacting patients’ quality of life. In recent years, photodynamic therapy (PDT) has garnered considerable attention as a promising technology for cancer...

Rapid and Large-Scale Synthesis of Chiral and Fluorescent Sulfur Quantum Dots for Intracellular Temperature Monitoring

Chemistry, Nanoscience, Analytical Chemistry, Physical Chemistry, Medicinal Chemistry, Materials Chemistry, Medicine, Medical Imaging, Life Sciences, Biochemistry,
sulfur quantum dots   amino acid   fluorescence   chirality   cellular imaging   temperature monitoring   inflammation diagnostics  

Rapid and Large-Scale Synthesis of Chiral Fluorescent Sulfur Quantum Dots for Intracellular Temperature Monitoring Academic Background Fluorescent nanomaterials have broad application potential in fields such as energy harvesting, lighting displays, communication and information technology, biology, and medicine. Among them, sulfur quantum dots (SQ...

Multimodal Imaging Unveils the Impact of Nanotopography on Cellular Metabolic Activities

Chemistry, Nanoscience, Materials Science, Medicine, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
nanotopography   nanopillar   cell metabolism   metabolic dynamics   multimodal imaging   multivariate analysis   unsupervised clustering  

The Impact of Nanotopography on Cellular Metabolic Activities: Multimodal Imaging Reveals New Insights Academic Background In the field of biomedicine, the interaction between cells and material surfaces is crucial for studying cell behavior, tissue engineering, and regenerative medicine. Nanoscale surface topography (nanotopography) has been shown...