PAF1/HIF1α Axis Rewires Glycolytic Metabolism to Fuel Aggressiveness of Pancreatic Cancer

Medicine, Oncology, Life Sciences, Biochemistry,
Pancreatic Cancer   Metabolic Reprogramming   Aerobic Glycolysis   PAF1/HIF1α Axis   Lactate Dehydrogenase A  

PAF1/HIF1α Axis Promotes Pancreatic Cancer Aggressiveness by Regulating Glycolytic Metabolism Background Pancreatic cancer (PC) is a highly aggressive malignant tumor, with pancreatic ductal adenocarcinoma (PDAC) being the most common type. Despite significant advancements in cancer treatment in recent years, the 5-year survival rate for pancreatic...

Phosphatidylinositol Promotes the Proliferation and Invasion of Pituitary Adenoma Cells by Regulating POU1F1 Expression

Medicine, Endocrinology, Oncology, Life Sciences, Biochemistry,
phosphatidylinositol   pituitary adenoma   POU1F1   metabolomics   proteomics   cell invasion   AKT/ERK signaling pathway  

Phosphatidylinositol Promotes Pituitary Adenoma Cell Proliferation and Invasion by Regulating POU1F1 Expression Background Pituitary adenoma (PA) is one of the most common primary intracranial tumors, accounting for approximately 15% of all intracranial tumors. Although most pituitary adenomas are benign, about 30% of them are invasive, known as in...

Similar Deficiencies, Different Outcomes: Succinate Dehydrogenase Loss in Adrenal Medulla vs. Fibroblast Cell Culture Models of Paraganglioma

Medicine, Endocrinology, Oncology, Life Sciences, Cell Biology, Biochemistry,
Succinate Dehydrogenase   Paraganglioma   Adrenal Medulla   Fibroblasts   Metabolism   Tumorigenesis   Hypoxic Signaling  

Different Manifestations of SDH Loss in Adrenal Medulla vs. Fibroblast Models Background Introduction Succinate dehydrogenase (SDH) is a key enzyme in the mitochondrial tricarboxylic acid (TCA) cycle and electron transport chain, responsible for oxidizing succinate to fumarate and participating in electron transfer. SDH consists of four subunits (S...

A Whole Food, Plant-Based Diet Reduces Amino Acid Levels in Patients with Metastatic Breast Cancer

Medicine, Oncology, Life Sciences, Biochemistry,
whole food plant-based diet   amino acids   cancer   diet   fat   carbohydrate   protein   fiber  

The Impact of a Whole Food, Plant-Based Diet on Amino Acid Levels in Patients with Metastatic Breast Cancer Research Background The growth and survival of cancer cells depend on significant metabolic demands, particularly for amino acids. Tumors meet these demands by acquiring amino acids from the surrounding microenvironment, and dietary amino aci...

PFKFB3-Dependent Redox Homeostasis and DNA Repair Support Cell Survival Under EGFR-TKIs in Non-Small Cell Lung Carcinoma

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
Non-small cell lung carcinoma   EGFR   PFKFB3   Oxidative stress   DNA repair   ROS-dependent cell death   Metabolic rewiring  

The Role of PFKFB3 in EGFR-TKIs Tolerance in Non-Small Cell Lung Cancer Background Introduction Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths worldwide. Epidermal growth factor receptor (EGFR) mutations are relatively common in NSCLC, accounting for approximately 15-30% of cases. Although EGFR tyrosine kin...

TDO2 Inhibition Counters Benzo[a]pyrene-Induced Immune Evasion and Suppresses Tumorigenesis in Lung Adenocarcinoma

Medicine, Oncology, Life Sciences, Biochemistry, Immunology,
Benzo[a]pyrene   TDO2   Immune evasion   Lung adenocarcinoma   Tryptophan metabolism   PD-L1   ICOSL  

The Role of TDO2 Inhibition in Lung Cancer Immune Evasion Background Introduction Lung cancer is one of the leading causes of cancer-related deaths worldwide, with smoking recognized as a primary cause of its occurrence. Cigarette smoke contains numerous carcinogens, among which benzo[a]pyrene (BAP), a polycyclic aromatic hydrocarbon, has been show...