GLUT1-targeted near-infrared fluorescence molecular imaging for precise intraoperative detection of breast cancer

Medicine, Medical Imaging, Oncology, Life Sciences, Biochemistry, Immunology,
breast cancer   GLUT1   intraoperative detection   near-infrared fluorescence   molecular imaging   tumor excision   precision surgery  

A Novel GLUT1-Targeted Fluorescence Imaging Tracer: Advances in Intraoperative Breast Cancer Detection Background and Problem Statement Breast cancer is one of the most common malignancies among women worldwide, with an estimated 2.3 million new cases and approximately 666,000 deaths globally in 2022. Surgical treatment for breast cancer typically ...

Spatial Multiomic Landscape of the Human Placenta at Molecular Resolution

Medicine, Obstetrics and Gynecology, Life Sciences, Cell Biology, Biochemistry, Immunology,
placenta   multiomics   molecular resolution   gene regulation   pregnancy complications  

A New Chapter in the Molecular Understanding of the Human Placenta: Breakthroughs in Spatial Multiomics Background and Research Questions The placenta is the first fetal organ to develop during human pregnancy and plays a critical role in ensuring successful gestation and healthy fetal development. Despite its importance, our understanding of the m...

Gene-Level Alignment of Single-Cell Trajectories

Medicine, Life Sciences, Cell Biology, Immunology, Genetics,
single-cell RNA sequencing   pseudotime trajectory inference   dynamic time warping   gene expression   cell state  

Gene-level Single-cell Trajectory Alignment: A New Method Based on Dynamic Programming The advent of single-cell RNA sequencing (scRNA-seq) technology has dramatically advanced biological research, enabling scientists to observe dynamic changes at the single-cell level over time and space. However, comparing such dynamics across samples or conditio...

Single-cell and spatially resolved interactomics of tooth-associated keratinocytes in periodontitis

Medicine, Oral Sciences, Life Sciences, Immunology,
periodontitis   single-cell RNA sequencing   keratinocytes   immune interactions   bacterial infection   spatial phenotyping   chronic inflammation  

Single-Cell and Spatially Resolved Interactomics of Tooth-Associated Keratinocytes: Exploring the Role of Structural Immunity in Periodontitis Background Periodontitis is a chronic inflammatory disease that affects the periodontal tissues and impacts billions of people globally, potentially resulting in tooth loss. It is primarily caused by polybac...

An Organotypic Atlas of Human Vascular Cells

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
vascular cells   single-cell transcriptomics   endothelial cells   mural cells   organotypic   molecular signatures   vascular diseases  

Decoding the Human Vascular System: A Comprehensive Multi-organ Single-cell Transcriptomic Study Reveals Vascular Cell Diversity Background Overview The human vascular system is a core component for sustaining life, comprising endothelial cells (ECs) and mural cells that span across all organ systems. Its functions extend beyond merely delivering b...

Single-cell RNA Sequencing of Peripheral Blood Links Cell-Type-Specific Regulation of Splicing to Autoimmune and Inflammatory Diseases

Medicine, Rheumatology and Immunology, Life Sciences, Immunology, Genetics,
Single-cell RNA sequencing   Splicing regulation   Autoimmune diseases   Inflammatory diseases   Cell-type specificity   Genetic diversity   Asian Immune Diversity Atlas  

Single-cell RNA Sequencing Reveals Cell-type-specific Splicing Regulation in Peripheral Blood Linked to Autoimmune and Inflammatory Diseases Background In recent years, rapid advancements in genomics research have provided deeper insights into the genetic basis of complex traits. However, the functional mechanisms underlying most disease-associated...