Single-cell RNA Sequencing Reveals Cell-type-specific Splicing Regulation in Peripheral Blood Linked to Autoimmune and Inflammatory Diseases Background In recent years, rapid advancements in genomics research have provided deeper insights into the genetic basis of complex traits. However, the functional mechanisms underlying most disease-associated...
A New Method for Scalable Spatial Transcriptomics via Large-Format Microarrays: The Birth of Array-Seq Technology Background and Research Motivation In recent years, spatiomolecular analyses have become pivotal tools in biomedical research and clinical pathology due to their ability to study how the spatial organization of cells and molecules withi...
Spatiotemporal Imprinting of Tissue-Resident Memory CD8 T Cell Diversity Background Tissue-resident memory CD8 T cells (TRM cells) provide long-term immune protection at barrier sites such as the intestine. However, the heterogeneity of TRM cells and the mechanisms underlying their formation remain incompletely understood. Previous studies have ide...
The Key Role of RELMβ in Food Allergy Academic Background Food allergy (FA) is a common immune system disorder, particularly prevalent among children. The occurrence of food allergy is associated with abnormal immune responses to food antigens, especially the dysregulation of type 2 immune responses. Type 2 immune responses are typically defense me...
Mitochondrial Transfer and Immune Evasion Mechanisms in the Tumor Microenvironment Academic Background Tumor cells evade immune system attacks, particularly by T cells, through various mechanisms in the Tumor Microenvironment (TME). Although Immune Checkpoint Inhibitors (ICIs) have achieved significant progress in the treatment of various cancers, ...
Photothermal MXene-Embedded Tannin-Eu³⁺ Particles as In Situ Bacterial Vaccines for Seawater-Immersed Infected Wounds Academic Background Seawater-immersed wounds are prone to severe infections due to the low temperature, high salinity, and bacteria-rich environment, which hinder wound healing. Traditional antibacterial strategies often fail to pro...