Design of a Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells

Design of a Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
Iron oxide nanoparticles   CD26   HSP90 inhibitor   Drug-induced senescence   Skin cells   Senolysis  

Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells Academic Background With the intensification of population aging, the accumulation of senescent cells is considered a significant hallmark of aging and age-related diseases. Senescent cells are not only associated...

Platelet-Activating Factor: A Potential Therapeutic Target to Improve Cancer Immunotherapy

Medicine, Oncology, Life Sciences, Immunology,
tumor microenvironment   immunosuppression   platelet-activating factor   neutrophils   cancer immunotherapy  

The Potential Role of Platelet-Activating Factor in Cancer Immunotherapy Background Cancer immunotherapy has been a significant breakthrough in cancer treatment in recent years, but its efficacy is still limited by the immunosuppressive mechanisms within the tumor microenvironment (TME). The TME supports the differentiation and proliferation of mye...

Patient-Derived Acellular Ascites Fluid Affects Drug Responses in Ovarian Cancer Cell Lines Through the Activation of Key Signalling Pathways

Medicine, Obstetrics and Gynecology, Oncology, Life Sciences, Immunology,
ovarian cancer   acellular ascites fluid   drug sensitivity   signalling pathways   chemoresistance  

Impact of Patient-Derived Acellular Ascites on Drug Responses in Ovarian Cancer Cell Lines Through Activation of Key Signaling Pathways Background Ovarian cancer is one of the deadliest gynecological malignancies, with a 5-year survival rate of only 30% for patients with advanced epithelial ovarian cancer (EOC). Although surgery and chemotherapy (e...

APOBEC3C-mediated NF-κB Activation Enhances Clear Cell Renal Cell Carcinoma Progression

Medicine, Nephrology, Oncology, Life Sciences, Biochemistry, Immunology,
Clear cell renal cell carcinoma   APOBEC3C   NF-κB   RNA-binding protein   Tumor progression  

APOBEC3C-Mediated NF-κB Activation Enhances Clear Cell Renal Cell Carcinoma Progression Academic Background Clear cell renal cell carcinoma (CCRCC) is the most common subtype of kidney cancer, accounting for approximately 75% of all kidney cancer cases. Although immunotherapy has shown some potential in treating CCRCC, the treatment of metastatic C...

Enhancing Immunotherapy Through PD-L1 Upregulation: The Promising Combination of Anti-PD-L1 Plus mTOR Inhibitors

Medicine, Urology, Oncology, Life Sciences, Immunology,
bladder cancer   PD-L1   mTOR inhibitors   immune checkpoint inhibitors   tumor microenvironment  

Enhancing Immunotherapy Potential Through PD-L1 Upregulation—Combination of Anti-PD-L1 and mTOR Inhibitors Background Introduction In recent years, immune checkpoint inhibitors (ICIs) have made significant progress in cancer treatment, particularly in the treatment of urothelial cancer (UC). PD-1/PD-L1 inhibitors restore T cell anti-tumor activity ...

IDH Mutation, Glioma Immunogenicity, and Therapeutic Challenge of Primary Mismatch Repair Deficient IDH-Mutant Astrocytoma (PMMRDIA): A Systematic Review

Medicine, Neurosurgery, Oncology, Life Sciences, Immunology,
IDH mutation   glioma   immunogenicity   mismatch repair deficiency   astrocytoma   therapeutic challenge   systematic review  

Immunogenicity and Therapeutic Challenges of IDH-Mutant Gliomas Background Glioma is a common central nervous system tumor, and its treatment and prognosis vary significantly depending on molecular characteristics. In recent years, the diagnostic and prognostic significance of isocitrate dehydrogenase (IDH) mutations in gliomas has been increasingl...