Signal Integrator Function of CXXC5 in Cancer Academic Background CXXC5 (CXXC-type zinc finger protein 5) is a member of the ZF-CXXC protein family and plays a pivotal role in signal integration and information transfer within the cellular signaling network. By regulating multiple signaling pathways (such as Wnt/β-catenin, TGF-β/BMP, ATM/p53, etc.)...

Discovery of a New Immunotherapy Target for Ewing Sarcoma Background Introduction Ewing sarcoma (Ewing’s sarcoma, EWS) is a common pediatric bone cancer, accounting for approximately 2% of childhood cancers. Despite significant advances in immune checkpoint inhibitors (ICIs) and CAR-T cell therapy in various cancers, their efficacy in Ewing sarcoma...

Targeting ERK1/2 and p38 MAPK Pathways Attenuates Golgin-97 Depletion-Induced Breast Cancer Progression Research Background Breast cancer is the most common type of cancer among women worldwide, with triple-negative breast cancer (TNBC) having a particularly high metastasis rate and poor prognosis. TNBC lacks expression of estrogen receptor, proges...

The Role of Histone Demethylases in Autophagy and Inflammation Background Introduction Autophagy is an essential lysosomal degradation process in eukaryotic cells, playing a critical role in cellular component renewal and homeostasis maintenance. Dysregulation of autophagy is associated with various diseases, including cancer, inflammatory diseases...

N88S Seipin-related Seipinopathy is a Lipidopathy Associated with Loss of Iron Homeostasis Academic Background Seipin is a protein encoded by the human BSCL2 gene and the yeast SEI1 gene, forming an endoplasmic reticulum (ER)-bound homo-oligomer. This oligomer plays a crucial role in targeting ER-lipid droplet (LD) contact sites, facilitating the d...

PRDX5 and PRDX6 in Oxidative Stress Response During Cryopreservation of Bull Sperm Academic Background Cryopreservation is a critical step in animal breeding and assisted reproductive technologies, particularly in the preservation of bull sperm. However, oxidative stress generated during cryopreservation significantly reduces sperm quality, leading...