Ubiquitin Regulatory X (UBX) Domain-Containing Protein 6 is Essential for Autophagy Induction and Inflammation Control in Macrophages

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology,
UBXN6   sepsis   inflammation   autophagy   immunosuppression  

Critical Role of UBXN6 in Autophagy Induction and Inflammation Control in Macrophages Background The innate immune system serves as the first line of defense against pathogen invasion and inflammatory responses. Monocytes and macrophages, as key cell types in the innate immune system, play critical roles during infection and inflammation. However, ...

Alternative mRNA Polyadenylation Regulates Macrophage Hyperactivation via the Autophagy Pathway

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology,
alternative polyadenylation   NUDT21   macrophage   autophagy   inflammation  

NUDT21 Regulates Macrophage Hyperactivation via the Autophagy Pathway Academic Background The inflammatory response is a critical component of the body’s immune defense, facilitating pathogen clearance and tissue repair. However, dysregulation of the inflammatory response can lead to chronic inflammatory diseases such as inflammatory bowel disease ...

Validation of the Online Collaborative Ocular Tuberculosis Study Calculator for Tubercular Uveitis

Medicine, Infectious Diseases, Ophthalmology, Life Sciences, Immunology,
Tubercular Uveitis   Antitubercular Therapy   Diagnostic Accuracy   Clinical Decision-Making   International Cohort   Ocular Tuberculosis   COTS Calculator  

Academic Background Tubercular Uveitis (TBU) is an ocular condition caused by Mycobacterium tuberculosis infection or immune-mediated inflammation. While tuberculosis (TB) remains a major global public health issue, the diagnosis and treatment of TBU continue to pose significant challenges. TBU presents a wide range of clinical manifestations, with...

Impact of Soluble BCMA and Non–T-Cell Factors on Refractoriness to BCMA-Targeting T-Cell Engagers in Multiple Myeloma

Medicine, Hematology, Oncology, Life Sciences, Immunology,
Soluble BCMA   Multiple Myeloma   T-Cell Engagers   Refractoriness   Tumor Burden   Surface Antigen Density   Therapeutic Optimization  

The Impact of Soluble B-Cell Maturation Antigen (sBCMA) on Multiple Myeloma Therapy: Interpreting the Latest Research Findings In recent years, cell-based immunotherapies have demonstrated enormous promise in the treatment of multiple myeloma (MM). Among these, BCMA-targeting T-cell engagers (TCEs) and chimeric antigen receptor (CAR) T-cell therapi...

Emapalumab Therapy for Hemophagocytic Lymphohistiocytosis Before Reduced-Intensity Transplantation Improves Chimerism

Medicine, Pediatrics, Hematology, Life Sciences, Immunology,
Hemophagocytic Lymphohistiocytosis   Chimerism   Reduced-Intensity Transplantation   Emapalumab   Intervention-Free Survival  

Research Report on Pre-HCT Emapalumab Therapy Improving Donor Chimerism in Children with HLH Background and Objective of the Study Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening immune disorder caused by pathological immune activation. The primary mechanism involves the functional deficiency of cytotoxic activity in natural killer (...

Prognostic Impact of Cytogenetic Abnormalities Detected by FISH in AL Amyloidosis with Daratumumab-Based Frontline Therapy

Medicine, Hematology, Oncology, Life Sciences, Immunology,
AL amyloidosis   daratumumab   cytogenetic abnormalities   FISH   prognosis   frontline therapy   hematologic response  

Review of the Impact of FISH-Detected Cytogenetic Abnormalities on Prognosis in AL Amyloidosis in the Era of Daratumumab Therapy Background Immunoglobulin light chain (AL) amyloidosis is a rare disease characterized by organ dysfunction caused by the deposition of light chain proteins secreted by abnormal plasma cells. However, the heterogeneous cl...