PRDX5 and PRDX6 Translocation and Oligomerization in Bull Sperm: A Response to Cryopreservation-Induced Oxidative Stress

Medicine, Obstetrics and Gynecology, Life Sciences, Cell Biology, Biochemistry, Immunology,
bull sperm   PRDX5   PRDX6   oxidative stress   cryopreservation   antioxidant proteins   sperm quality  

PRDX5 and PRDX6 in Oxidative Stress Response During Cryopreservation of Bull Sperm Academic Background Cryopreservation is a critical step in animal breeding and assisted reproductive technologies, particularly in the preservation of bull sperm. However, oxidative stress generated during cryopreservation significantly reduces sperm quality, leading...

Staphylococcus aureus Vesicles Impair Cutaneous Wound Healing through p38 MAPK-MERTK Cleavage-Mediated Inhibition of Macrophage Efferocytosis

Medicine, Infectious Diseases, Life Sciences, Cell Biology, Immunology, Microbiology,
Staphylococcus aureus   extracellular vesicles   wound healing   efferocytosis   MERTK  

Staphylococcus Aureus Vesicles Impair Cutaneous Wound Healing Through p38 MAPK-MerTK Cleavage-Mediated Inhibition of Macrophage Efferocytosis Background Introduction Staphylococcus aureus (S. aureus) is one of the primary pathogens causing chronic wound infections, particularly in diabetic patients, with an infection rate as high as 65%. One of the...

Kindlin-3 but not Talin-1 Contributes to β2 Integrin Clustering

Medicine, Life Sciences, Cell Biology, Immunology,
integrin clustering   Kindlin-3   Talin-1   neutrophils   inflammatory response   super-resolution microscopy   signaling  

The Critical Role of Kindlin-3 in β2 Integrin Clustering Academic Background Neutrophils are the most abundant type of white blood cells in human blood, and their recruitment is essential for innate immunity and inflammatory responses. The initial and critical step in neutrophil recruitment is their adhesion to vascular endothelial cells, which dep...

Induction of Tertiary Lymphoid Structures in the Glioma Microenvironment and Their Role in Anti-Glioma Immunity

Medicine, Neurology, Oncology, Life Sciences, Immunology,
glioma   tertiary lymphoid structures   immunotherapy   tumor microenvironment   Toll-like receptor agonists  

Induction of Tertiary Lymphoid Structures in Glioma Immunotherapy and Their Anti-Tumor Immune Effects Background Introduction Glioma is a highly malignant brain tumor characterized by limited lymphocyte infiltration in the tumor microenvironment (glioma microenvironment, GME), presenting an “immune desert” state. This characteristic makes glioma in...

Mevalonate Kinase Inhibits Anti-Tumor Immunity by Impairing the Tumor Cell-Intrinsic Interferon Response in Microsatellite Instability Colorectal Cancer

Medicine, Oncology, Life Sciences, Immunology,
Mevalonate Kinase   Microsatellite Instability Colorectal Cancer   Interferon Response   Immune Checkpoint Blockade   Cholesterol Metabolism  

Mevalonate Kinase Impairs Anti-Tumor Immunity by Inhibiting the Tumor Cell-Intrinsic Interferon Response in Microsatellite Instability Colorectal Cancer Academic Background Immune checkpoint blockade (ICB) therapy, particularly anti-PD-1 monoclonal antibodies, has been approved for the treatment of microsatellite instability colorectal cancer (MSI ...

CBL0137 and NKG2A Blockade: A Novel Immuno-Oncology Combination Therapy for MYC-Overexpressing Triple-Negative Breast Cancers

Medicine, Oncology, Life Sciences, Immunology,
Triple-negative breast cancer   MYC overexpression   CBL0137   NKG2A blockade   Immunotherapy   Tumor microenvironment   Immune suppression  

Academic Background and Problem Statement Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer, accounting for 15-20% of all breast cancer cases. Due to the lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), TNBC is insensitive to hormone the...