CBL0137 and NKG2A Blockade: A Novel Immuno-Oncology Combination Therapy for MYC-Overexpressing Triple-Negative Breast Cancers

Medicine, Oncology, Life Sciences, Immunology,
Triple-negative breast cancer   MYC overexpression   CBL0137   NKG2A blockade   Immunotherapy   Tumor microenvironment   Immune suppression  

Academic Background and Problem Statement Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer, accounting for 15-20% of all breast cancer cases. Due to the lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), TNBC is insensitive to hormone the...

Senescent Lung Fibroblasts in Idiopathic Pulmonary Fibrosis Facilitate Non-Small Cell Lung Cancer Progression by Secreting Exosomal MMP1

Medicine, Respiratory System, Oncology, Life Sciences, Cell Biology, Immunology,
Idiopathic Pulmonary Fibrosis   Non-Small Cell Lung Cancer   Exosomes   MMP1   PI3K-AKT-mTOR Pathway   Senescence-Associated Secretory Phenotype   Tumor Microenvironment  

Academic Background and Problem Statement Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease associated with aging and is an independent risk factor for lung cancer. Epidemiological studies indicate that 3%-22% of IPF patients develop lung cancer during follow-up, with the cumulative incidence increasing over time, makin...

Tissue Factor Promotes TREX1 Protein Stability to Evade cGAS-STING Innate Immune Response in Pancreatic Ductal Adenocarcinoma

Medicine, Pharmacy, Oncology, Life Sciences, Immunology,
Pancreatic Ductal Adenocarcinoma   Tissue Factor   TREX1 Protein   cGAS-STING Pathway   Immune Evasion   Tumor Microenvironment   Targeted Therapy  

Tissue Factor Promotes TREX1 Protein Stability to Evade cGAS-STING Innate Immune Response in Pancreatic Ductal Adenocarcinoma Academic Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging malignancies worldwide, with increasing incidence and mortality rates, particularly in advanced stages. Despite significant prog...

TFF3 Drives Hippo-Dependent EGFR-TKI Resistance in Lung Adenocarcinoma

Medicine, Respiratory System, Oncology, Life Sciences, Cell Biology, Immunology,
Lung Adenocarcinoma   EGFR-TKI Resistance   TFF3   Hippo Signaling Pathway   YAP Protein   Molecular Targeted Therapy   Cancer Resistance Mechanisms  

TFF3 Drives Hippo-Dependent EGFR-TKI Resistance in Lung Adenocarcinoma Academic Background Lung adenocarcinoma (LUAD) is one of the most common subtypes of non-small cell lung cancer (NSCLC), with frequent mutations in the epidermal growth factor receptor (EGFR). Since 2013, EGFR tyrosine kinase inhibitors (TKIs) such as gefitinib, erlotinib, and o...

Pseudokinase TRIB3 Stabilizes SSRP1 via USP10-Mediated Deubiquitination to Promote Multiple Myeloma Progression

Pseudokinase TRIB3 Stabilizes SSRP1 via USP10-Mediated Deubiquitination to Promote Multiple Myeloma Progression

Medicine, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Multiple Myeloma   Pseudokinase TRIB3   SSRP1   USP10   Deubiquitination   Therapeutic Target   Drug Intervention  

TRIB3 Promotes Multiple Myeloma Progression by Stabilizing SSRP1 via USP10-Mediated Deubiquitination Academic Background Multiple Myeloma (MM) is the second most common hematologic malignancy globally, characterized by aggressive progression, frequent relapse, and resistance to therapy. Although current multi-drug combination therapies have signifi...

LGALS9B stabilizes EEF1D protein and activates the PI3K/AKT signaling pathway to promote gastric cancer occurrence and metastasis

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
gastric cancer   LGALS9B   EEF1D   PI3K/AKT signaling pathway   tumor metastasis   cell proliferation   molecular mechanism  

lgals9b Stabilizes eef1d Protein and Activates the PI3K/AKT Signaling Pathway to Promote Gastric Cancer Occurrence and Metastasis Academic Background Gastric cancer ranks as the fifth most prevalent cancer globally, with over one million new cases diagnosed annually. Due to late detection, it exhibits a high mortality rate and is the fourth leading...