Effect of Neoadjuvant Chemoradiotherapy with or without PD-1 Antibody Sintilimab in PMMR Locally Advanced Rectal Cancer: A Randomized Clinical Trial

Medicine, Gastroenterology, Oncology, Life Sciences, Immunology,
neoadjuvant chemoradiotherapy   PD-1 antibody   locally advanced rectal cancer   sintilimab   complete response rate  

The Role of Neoadjuvant Chemoradiotherapy Combined or Not Combined with PD-1 Antibody Sintilimab in pMMR Locally Advanced Rectal Cancer: Results of a Randomized Clinical Trial Background and Significance The management of rectal cancer and organ preservation has always been quite challenging, especially in cases of locally advanced rectal cancer (L...

Coagulation Factor X Promotes Resistance to Androgen-Deprivation Therapy in Prostate Cancer

Medicine, Urology, Oncology, Life Sciences, Biochemistry, Immunology,
prostate cancer   androgen-deprivation therapy   coagulation factor X   immunosuppression   tumor microenvironment  

Study on the Role of Coagulation Factor X in Anti-androgen Resistance in Prostate Cancer Research Background Prostate cancer (PCa) is the second most common cancer in men worldwide and is one of the leading causes of cancer-related deaths. The occurrence and progression of prostate cancer are highly dependent on the androgen receptor (AR) signaling...

Tumor Architecture and Microenvironment Features in Brain Metastasis of Breast Cancer

Tumor Architecture and Microenvironment Features in Brain Metastasis of Breast Cancer

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
breast cancer   brain metastasis   tumor architecture   microenvironment   immune response  

Specific Tumor Structures and Microenvironment of Breast Cancer Metastasis to the Brain: A Research Review Research Background Brain metastasis is one of the severe complications faced by breast cancer patients, leading to complex neurological complications and low survival rates, with very limited treatment options. Among the various subtypes of b...

FUS/CircZEB1/miR-128-3p/LBH Feedback Loop Promotes Malignant Phenotype of GSCs via TNF-α Mediated NF-κB Signaling Pathway

Medicine, Neurology, Oncology, Life Sciences, Biochemistry, Immunology, Genetics,
Glioblastoma   CircZEB1   Glioma Stem Cells   Limb-Bud and Heart   NF-κB Signaling Pathway  

The Role of the Novel Circular RNA circZEB1 in the Malignant Phenotype of Glioblastoma Stem Cells and Its Molecular Mechanism Research Background Glioblastoma (GBM) is one of the most aggressive and fatal primary tumors in the central nervous system, with a very poor prognosis for patients. Even with surgery, radiotherapy, and chemotherapy, the ave...

Life History Dynamics of Evolving Tumors: Insights into Task Specialization, Trade-offs, and Tumor Heterogeneity

Medicine, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
tumor evolution   task specialization   heterogeneity   trade-offs   tumor microenvironment  

Cancer Cell International - Review Report Background and Motivation In recent decades, research into cancer evolution has gradually revealed that the evolutionary patterns of cancer cells share many similarities with species evolution. This notion has changed our understanding of tumor evolution and heterogeneity. Cancer is initiated by the mutatio...

Identification and Validation of a Prognostic Model Based on Three TLS-Related Genes in Oral Squamous Cell Carcinoma

Medicine, Oral Sciences, Medical Imaging, Oncology, Life Sciences, Biochemistry, Immunology, Genetics,
oral squamous cell carcinoma   tertiary lymphoid structure   prognostic model   immune infiltration   convolutional neural network  

Research Report: Validation and Analysis of a Prognostic Model for Oral Squamous Cell Carcinoma Constructed with TLS-Related Genes Background and Research Motivation Oral Squamous Cell Carcinoma (OSCC) is the most common subtype of Head and Neck Squamous Cell Carcinoma (HNSCC), exhibiting a high tendency for lymph node metastasis, especially to the...