Targeting the Transferrin Receptor to Transport Antisense Oligonucleotides Across the Mammalian Blood-Brain Barrier

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Pharmacy, Life Sciences, Cell Biology, Biochemistry, Immunology,
transferrin receptor   antisense oligonucleotides   blood-brain barrier   central nervous system   drug delivery  

Introduction In recent years, oligonucleotide-based therapeutic technologies, such as antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), have been widely applied in the treatment of various neurological disorders. The basis for their application is that these technologies can selectively regulate target RNA molecules, which are ...

A PRM Mutation that Attenuates Dengue Virus Replication in Human Cells Enhances Midgut Infection in Mosquitoes

Medicine, Infectious Diseases, Life Sciences, Cell Biology, Immunology, Microbiology,
Dengue Virus   PRM Mutation   Virus Replication   Mosquito Infection   1970s   South Pacific   Epidemiology  

Dengue Virus Research: Impact of Genetic Mutations on Virus Transmission and Discoveries Introduction This study was conducted by Allyson N. X. Choi et al. and published in Science Translational Medicine on July 31, 2024. The research aims to reveal the impact of genetic changes in dengue virus on its transmission ability and disease outbreaks duri...

MGA Deletion Leads to Richter’s Transformation by Modulating Mitochondrial OXPHOS

Medicine, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
MGA   Richter's transformation   mitochondria   OXPHOS   CLL  

MGA Deletion Promotes Richter’s Transformation by Regulating Mitochondrial Oxidative Phosphorylation This article mainly focuses on the transformation of chronic lymphocytic leukemia (CLL) into aggressive lymphoma, known as Richter’s Transformation (RT), exploring the function and molecular mechanism of MGA (MAX Gene Associated). MGA is a functiona...

A Self-Amplifying RNA Vaccine Prevents Enterovirus D68 Infection and Disease in Preclinical Models

Medicine, Infectious Diseases, Respiratory System, Life Sciences, Bioengineering, Immunology, Microbiology,
RNA vaccine   Enterovirus D68   nonenveloped virus   antibody responses   vaccine platform   antigenic diversity   preventive vaccine  

A Study on Self-Amplifying RNA Vaccine for Prevention of Enterovirus D68 Infection and Disease in Clinical Models 1. Background In recent years, rapid response to emerging infectious diseases and vaccine development have received much attention. Particularly, the emergence of the novel coronavirus (SARS-CoV-2) has led to rapid advancement in RNA va...

Neural Landscape is Associated with Functional Outcomes in Irradiated Patients with Oropharyngeal Squamous Cell Carcinoma

Medicine, Oral Sciences, Neurology, Neurosurgery, Medical Imaging, Oncology, Life Sciences, Immunology,
Neural landscape   Radiation therapy   Oropharyngeal squamous cell carcinoma   Dysphagia   Neuronal changes   Quality improvement   Functional outcomes  

Research on the Association between Neural Networks and Functional Outcomes in Radiotherapy Patients with Pharyngeal Cancer 1. Paper Background Introduction The incidence of human papillomavirus (HPV)-mediated oropharyngeal squamous cell carcinoma (OPSCC) has significantly increased over the past 40 years, especially among younger populations with ...

In Vivo Bruton's Tyrosine Kinase Inhibition Attenuates Alcohol-Associated Liver Disease by Regulating CD84-Mediated Granulopoiesis

Medicine, Infectious Diseases, Hepatobiliary System, Gastroenterology, Hematology, Life Sciences, Biochemistry, Immunology,
Bruton's Tyrosine Kinase   Alcohol-Associated Liver Disease   Granulopoiesis   Neutrophils   Liver Damage   Therapeutic Target  

Research Background Severe alcoholic hepatitis (ALD) is a fatal form of alcohol-associated liver disease (AALD). The course of ALD is usually accompanied by neutrophil infiltration in the liver, which significantly affects the severity of the condition. However, the specific effects of alcohol on neutrophil function remain unclear. Based on this, i...