Identification and Validation of a Prognostic Model Based on Three TLS-Related Genes in Oral Squamous Cell Carcinoma

Medicine, Oral Sciences, Medical Imaging, Oncology, Life Sciences, Biochemistry, Immunology, Genetics,
oral squamous cell carcinoma   tertiary lymphoid structure   prognostic model   immune infiltration   convolutional neural network  

Research Report: Validation and Analysis of a Prognostic Model for Oral Squamous Cell Carcinoma Constructed with TLS-Related Genes Background and Research Motivation Oral Squamous Cell Carcinoma (OSCC) is the most common subtype of Head and Neck Squamous Cell Carcinoma (HNSCC), exhibiting a high tendency for lymph node metastasis, especially to the...

A Multidimensional Analysis of the Impact of Obesity on Immune Checkpoint Inhibitor Therapy Efficacy

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Immunology,
obesity   immune checkpoint inhibitors   inflammation   survival rate   cancer  

Background and Research Motivation Obesity has been identified as an important risk factor for various malignancies. It not only promotes the growth and spread of tumor cells but also leads to generally poorer prognosis in patients. However, recent research has found that obese patients receiving immune checkpoint inhibitors (ICI) therapy, especial...

The Clinical and Genetic Spectrum of Inherited Glycosylphosphatidylinositol Deficiency Disorders

Medicine, Pediatrics, Basic Medical Sciences, Neurology, Medical Imaging, Life Sciences, Cell Biology, Immunology, Genetics,
Inherited   Glycosylphosphatidylinositol Deficiency   Multisystem Disorders   Neurogenetic Disease   Molecular Spectrum   Natural History Data  

Clinical and Genetic Spectrum Study of Inherited Glycosylphosphatidylinositol Deficiency Disorders (IGDs) Background Introduction The glycosylphosphatidylinositol (GPI) anchoring pathway is crucial for post-translational modification of many important proteins in eukaryotes, which are fundamental for cell signaling and early human neurogenesis and ...

Stress-Induced Eosinophil Activation Contributes to Postoperative Morbidity and Mortality After Lung Resection

Medicine, Infectious Diseases, Respiratory System, Basic Medical Sciences, Life Sciences, Immunology,
stress   eosinophils   lung resection   postoperative complications   lung injury  

Research Background With global population aging, the number of lung resection surgeries has increased significantly, including primary lung cancer resection, removal of lung metastases, and surgeries to treat lung infections or emphysema. However, little is known about the systemic stress response after thoracic surgery and interventions to improv...

Neuronal A2A Receptor Exacerbates Synapse Loss and Memory Deficits in APP/PS1 Mice

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Immunology,
adenosine A2A receptor   Alzheimer's disease   synapse loss   memory deficits   neuroinflammation  

A2A Adenosine Receptor Exacerbates Synaptic Loss and Memory Deficits in APP/PS1 Mice Alzheimer’s disease (AD) is a neurodegenerative disorder associated with progressive cognitive decline, characterized by the deposition of extracellular β-amyloid (Aβ) plaques and the accumulation of hyperphosphorylated tau protein in neurons. Some epidemiological ...

Microglia-specific IL-10 Gene Delivery Inhibits Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Microglia   IL-10   Neuroinflammation   Neurodegeneration   Parkinson's Disease  

Parkinson’s Disease Mouse Model: IL-10 Gene Delivery Inhibits Neuroinflammation and Neurodegeneration As research into the pathogenesis of Parkinson’s Disease (PD) deepens, the role of neuroinflammation in PD is gradually being revealed. This study by Simone Bido and his team, published in “Science Translational Medicine”, explores the effects of t...