Role of Recurrent Somatic Mutation and Progerin Expression in Early Vascular Aging of Chronic Kidney Disease

Medicine, Basic Medical Sciences, Geriatrics, Nephrology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Genetics,
chronic kidney disease   vascular aging   somatic mutations   progerin   vascular smooth muscle cells   clonal expansion   molecular mechanisms  

1. Academic Background and Research Rationale Chronic Kidney Disease (CKD) is a global public health challenge. Epidemiological data indicate that CKD affects approximately 10–12% of the world’s population, acting as a major driver of cardiovascular disease (CVD) mortality worldwide. CKD patients often display “Early Vascular Aging” (EVA) phenomena...

Large-scale plasma proteomic profiling unveils diagnostic biomarkers and pathways for Alzheimer's disease

Information Science, Artificial Intelligence, Medicine, Medical Laboratory Science, Geriatrics, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
Alzheimer's disease   proteomics   biomarkers   plasma proteins   disease diagnosis   pathway analysis  

1. Research Background and Academic Significance Alzheimer’s Disease (AD) is the most common form of dementia worldwide, accounting for about 60–80% of all dementia cases. The primary affected population is individuals over 65 years old, with characteristic pathological features including the deposition of amyloid-β plaques, neurofibrillary tangles...

Mitochondria-Enriched Hematopoietic Stem Cells Exhibit Elevated Self-Renewal Capabilities Within the Context of Aged Bone Marrow

Medicine, Basic Medical Sciences, Geriatrics, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
hematopoietic stem cells   mitochondria   self-renewal   aging   bone marrow   single-cell analysis   cell differentiation  

Mitochondria-Enriched Hematopoietic Stem Cells Reveal Enhanced Self-Renewal Activity in Aged Bone Marrow: In-Depth Analysis of the Latest Study in Nature Aging I. Academic Background and Research Significance Hematopoietic stem cells (HSCs) are the essential foundation underlying life-long production of blood and immune cells. However, with aging, ...

Retrotransposon-Derived Capsid Genes PNMA1 and PNMA4 Maintain Reproductive Capacity

Medicine, Obstetrics and Gynecology, Geriatrics, Endocrinology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics, Biophysics,
retrotransposon   capsid genes   PNMA1   PNMA4   reproductive capacity   gonadal tissue   evolution  

Mechanistic Study on How Retrotransposon-derived Capsid Genes PNMA1 and PNMA4 Maintain Reproductive Capacity — A New Research Review from Nature Aging I. Research Background and Scientific Significance Nearly half of the DNA in the human and mammalian genome is made up of retrotransposons, sequences that originally existed as “parasitic molecules” ...

Large-Scale Network Analysis of the Cerebrospinal Fluid Proteome Reveals Molecular Signatures of Frontotemporal Lobar Degeneration

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
frontotemporal lobar degeneration   cerebrospinal fluid   proteomics   network analysis   genetic mutations   biomarkers  

Analysis of Large-Scale Network Study of the CSF Proteome in FTLD — Unlocking Molecular Signatures of Neurodegenerative Diseases I. Academic Background and Motivation Frontotemporal Lobar Degeneration (FTLD) is one of the most common causes of early-onset dementia (under age 65), triggering a range of progressive behavioral, language, and even moto...

The Role of mRNA Metabolism Regulator Human Antigen R (HuR) in Age-Related Hearing Loss in Aged Mice

Medicine, Basic Medical Sciences, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
mRNA metabolism   HuR   age-related hearing loss   hair cells   auditory function   AAV gene therapy   cochlea  

mRNA Metabolism Regulator Human Antigen R (HuR) Regulates Age-Related Hearing Loss in Aged Mice — A Systematic Study of Molecular Pathological Mechanisms and Therapeutic Intervention 1. Academic Background and Scientific Questions Age-related hearing loss (ARHL), also known as presbycusis, is one of the most common sensory disorders in the global e...