Intelligent Conversational Agent for Rare Diseases—RDGuru: Cutting-edge Technology Powers a New Revolution in Clinical Diagnosis Academic Background and Research Motivation Rare Diseases (RD) refer to disease categories that affect fewer than 6.5 to 10 individuals per 10,000 population. Their individual rarity, complex clinical features, and divers...
1. Academic Background: The Mysterious Link between X Chromosome Inactivation and Aging In mammals, females possess two X chromosomes while males have only one. To maintain gene dosage balance between the sexes, females undergo a process called X chromosome inactivation (XCI) early in development, in which one of the two X chromosomes is randomly s...
Unveiling the Mystery of the Epigenetic Aging Clock: A Review of Research on the Impact of Epigenetic Editing at Single Age-Associated CpG Sites on the Genome-wide Epigenetic Aging Landscape I. Research Background and Scientific Questions Epigenetics, especially DNA methylation, has become a cutting-edge frontier in aging mechanism research in rece...
1. Research Background and Significance With global population aging on the rise, the incidence of metabolic dysfunction-associated steatohepatitis (MASH, also known as NASH) and related chronic liver diseases such as hepatic fibrosis is increasing year by year. These disorders have become a major focus and challenge in basic and clinical hepatolog...
— Longitudinal Population Analysis Based on the “Pace of Aging” Method 1. Research Background and Scientific Significance With the acceleration of global population aging, objectively measuring and improving the health status of the elderly has become an important issue in social policy and public health worldwide. Traditionally, measurements of po...
1. Academic Background and Research Rationale Chronic Kidney Disease (CKD) is a global public health challenge. Epidemiological data indicate that CKD affects approximately 10–12% of the world’s population, acting as a major driver of cardiovascular disease (CVD) mortality worldwide. CKD patients often display “Early Vascular Aging” (EVA) phenomena...