The Role of mRNA Metabolism Regulator Human Antigen R (HuR) in Age-Related Hearing Loss in Aged Mice

Medicine, Basic Medical Sciences, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
mRNA metabolism   HuR   age-related hearing loss   hair cells   auditory function   AAV gene therapy   cochlea  

mRNA Metabolism Regulator Human Antigen R (HuR) Regulates Age-Related Hearing Loss in Aged Mice — A Systematic Study of Molecular Pathological Mechanisms and Therapeutic Intervention 1. Academic Background and Scientific Questions Age-related hearing loss (ARHL), also known as presbycusis, is one of the most common sensory disorders in the global e...

Transcriptomic Analysis of the m6A Reader YTHDF2 in the Maintenance and Differentiation of Human Embryonic Stem Cells

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
m6A modification   YTHDF2   human embryonic stem cells   neuroectoderm differentiation   transcriptomics   ROBO1  

1. Research Background and Significance Over the past decade, the role of epigenetics in regulating cell fate decisions and disease development has become increasingly prominent. As a crucial part of epigenetic regulation, modifications at the RNA level—especially N6-methyladenosine (m6A)—have been confirmed to be widely present within eukaryotic m...

Inflammatory Pathways and the Bone Marrow Microenvironment in Inherited Bone Marrow Failure Syndromes

Medicine, Pediatrics, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
inherited bone marrow failure syndromes   inflammation   pro-inflammatory cytokines   bone marrow microenvironment   mesenchymal stromal cells   hematopoietic stem cells   cytokine network  

Inflammatory Pathways and Bone Marrow Microenvironment in Inherited Bone Marrow Failure Syndromes: New Insights into Chronic Inflammation Research Background and Academic Significance Inherited bone marrow failure syndromes (IBMFS) are a group of genetic disorders characterized by reduced hematopoietic cell production due to blood stem cell dysfunc...

RUNX1 is a Key Inducer of Human Hematopoiesis Controlling Non-Hematopoietic Mesodermal Development

Medicine, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
RUNX1   hematopoiesis   non-hematopoietic mesoderm   mesenchymal cells   transcription factor   human development   stem cell differentiation  

The Dominant Role of RUNX1 in Human Hematopoietic Development and Mesodermal Fate Balance — An Interpretation of “runx1 is a key inducer of human hematopoiesis controlling non-hematopoietic mesodermal development” 1. Academic Background and Research Motivation The development of the hematopoietic system is fundamental for the growth and maintenance...

Single Antisense Oligonucleotides Correct Diverse Splicing Mutations in Hotspot Exons

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
antisense oligonucleotide   splicing mutation   hotspot exon   RNA splicing   actionable genes   gene mutation   therapeutic strategy  

Broad-Spectrum Correction of Splicing Mutations in Rare Disease Hotspot Exons by Single Antisense Oligonucleotide: Review of a Recent 2025 PNAS Study I. Academic Background: The Challenge of Disease-Associated Splicing Mutations and Dilemmas in Antisense Therapy RNA splicing is a crucial step in the regulation of gene expression in eukaryotes. The ...

Pathogenic Variants in the Polycystin Pore Helix Cause Distinct Forms of Channel Dysfunction

Medicine, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Genetics, Biophysics,
autosomal dominant polycystic kidney disease   polycystin   PKD2   ion channels   cryo-EM   channel dysfunction   protein assembly  

Molecular Mechanism Analysis of ADPKD Pathogenic Variants in Ion Channels – In-depth Interpretation of PNAS 2025 Latest Original Research I. Academic Research Background and Scientific Significance Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common monogenic disorders worldwide, affecting millions of individuals. The pat...