In Vitro Model of Vertebrate Trunk Development Academic Background The development of the vertebrate trunk is a highly coordinated process involving the generation and organization of multiple cell types. At the core of this process are progenitor cells located in the posterior of the embryo, which differentiate into tissues such as the neural tube...
Report on the Academic Paper Paper Source The paper, titled “Modulation of TCR Stimulation and Pifithrin-α Improves the Genomic Safety Profile of CRISPR-Engineered Human T Cells,” was authored by Laurenz T. Ursch, Jule S. Müschen, Julia Ritter, and others from institutions such as the Technical University of Munich and the University of Freiburg Me...
Academic Background The tumor microenvironment (TME) is a critical area in cancer research, where tumor cells interact with surrounding non-tumor cells to influence disease progression and therapeutic responses. Tumor-associated macrophages (TAMs) play a pivotal role in tumor growth, angiogenesis, and immune suppression. Recently, the role of metab...
Report on the Academic Paper: “Multi-modal Analysis Reveals Tumor and Immune Features Distinguishing EBV-positive and EBV-negative Post-transplant Lymphoproliferative Disorders” Summary The Epstein-Barr virus (EBV) is a widely disseminated gamma-1 herpesvirus that infects approximately 90%-95% of adults globally. While EBV infection is typically as...
Miltefosine Reinvigorates Exhausted T Cells by Targeting Their Bioenergetic State Academic Background T cell exhaustion is a significant challenge in immunotherapy, particularly in cancer treatment. It typically occurs when T cells are chronically exposed to antigen stimulation, leading to a gradual loss of function, characterized by reduced effect...
Academic Background Diabetes is a global health issue affecting over 500 million people. Both type 1 diabetes (T1D) and type 2 diabetes (T2D) share the common feature of a significant reduction in the number of functional insulin-secreting beta cells. Therefore, restoring or increasing beta cell mass is considered a key strategy in diabetes treatme...