Single-Cell Analysis Reveals Differences Between Aged and Young Mouse Prostates Academic Background The prostate is a vital component of the male reproductive system. As men age, the prostate undergoes hyperplasia, which can lead to urethral compression, resulting in voiding dysfunction and associated symptoms, as well as an increased risk of prost...
The Spatial Impact of a Western Diet in Enriching Galectin-1-Regulated Rho, ECM, and SASP Signaling in a Novel MASH-HCC Mouse Model Academic Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and metabolic dysfunction-associated steatohepatitis (MASH) is one of the primary triggers of HCC. With ...
Combined Single-Cell and Spatial Transcriptome Analysis Reveals Cellular Heterogeneity of the Hedgehog Pathway in Gastric Cancer Academic Background Gastric cancer (GC) is one of the most common and deadly malignancies worldwide, with high incidence and mortality rates. Despite advancements in chemotherapy, radiotherapy, and targeted therapy, the t...
Academic Background Liver regeneration is a complex biological process involving the coordinated action of various cell types and signaling pathways. Following partial liver resection, the remaining liver tissue restores its function and mass through a series of precisely regulated cell proliferation and immune responses. Although extensive researc...
Automated Analysis of Ultrastructure: A Study Based on Large-Scale Hyperspectral Electron Microscopy Academic Background Electron Microscopy (EM) is a key technique for studying biological ultrastructure, revealing the fine details of cells at biomolecular resolution. In recent years, advancements in automation and digitization have enabled EM to c...
Academic Background and Problem Statement Mitochondria, as crucial organelles in eukaryotic cells, are involved in cellular energy metabolism, signal transduction, and the regulation of cell survival and death. Mitochondrial dysfunction is associated with various human diseases, including neurodegenerative disorders, cardiovascular diseases, diabet...