Oscillatory Contractile Forces Refine Endothelial Cell-Cell Interactions for Continuous Lumen Formation Governed by Heg1/CCM1

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Biophysics,
oscillatory contractile forces   endothelial cells   Heg1   CCM1   lumen formation   cell-cell interactions   angiogenesis  

Academic Background The formation and maintenance of vascular networks are critical processes in embryonic development and tissue regeneration, involving the regulation of various biophysical forces. Endothelial cells (ECs) play a central role in angiogenesis and vasculogenesis, with the contractile forces of the cytoskeleton (actomyosin contractil...

The Influences of APOE Isoforms on Endothelial Adherens Junctions and Actin Cytoskeleton Responding to MCRP

Medicine, Geriatrics, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
APOE   Monomeric C-reactive protein   Endothelial cells   Cytoskeleton   Alzheimer's disease   Cerebrovascular   F-actin  

Research Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the deposition of amyloid-beta (Aβ) plaques and abnormal phosphorylation of tau protein. Recent studies have increasingly highlighted the role of cerebrovascular alterations in the pathogenesis of AD. Specifically, endothelial cell damage and inflam...

Advanced Single-Cell and Spatial Analysis with High-Multiplex Characterization of Circulating Tumor Cells and Tumor Tissue in Prostate Cancer: Unveiling Resistance Mechanisms with the CODuco In Situ Assay

Medicine, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Circulating Tumor Cells (CTCs)   Metastatic Prostate Cancer   Multiplex Padlock Probe In Situ Hybridization   Single-Cell Gene Expression   Liquid Biopsy   Spatial Transcriptomics   Neuroendocrine Transdifferentiation  

Research Report on the Academic Paper Title: Advanced Single-Cell and Spatial Analysis with High-Multiplex Characterization of Circulating Tumor Cells and Tumor Tissue in Prostate Cancer: Unveiling Resistance Mechanisms with the CODuco In Situ Assay Authors: Lilli Bonstingl et al. Journal: Biomarker Research (2024) 12:140 DOI: 10.1186/s40364-024-00...

FBXL16: A New Regulator of Neuroinflammation and Cognition in Alzheimer’s Disease through the Ubiquitination-Dependent Degradation of Amyloid Precursor Protein

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
FBXL16   ubiquitination   Alzheimer’s disease   neuroprotection   amyloid precursor protein  

FBXL16: A New Regulator of Neuroinflammation and Cognition in Alzheimer’s Disease through Ubiquitination-Dependent Degradation of Amyloid Precursor Protein Academic Background Alzheimer’s Disease (AD) is an age-related neurodegenerative disorder characterized by progressive cognitive decline. With the global aging population, the incidence of neuro...

BRD4 Inhibitor Reduces Exhaustion and Blocks Terminal Differentiation in CAR-T Cells by Modulating BATF and EGR1

Medicine, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CAR-T cell exhaustion   BRD4 inhibitor   single-cell RNA sequencing   transcriptional factors   acute myeloid leukemia  

Acute myeloid leukemia (AML) is the most common type of leukemia in adults. Although most AML patients achieve complete remission after standard chemotherapy, refractory and relapsed disease remain a significant challenge. Over the past decade, immunotherapy has been widely applied in cancer treatment, particularly chimeric antigen receptor T-cell ...

Single-Cell Analysis Reveals Alterations Between the Aged and Young Mice Prostates

Medicine, Urology, Life Sciences, Cell Biology, Immunology,
Single-cell RNA sequencing   Prostate aging   Cellular heterogeneity   Gene expression   Mouse model  

Single-Cell Analysis Reveals Differences Between Aged and Young Mouse Prostates Academic Background The prostate is a vital component of the male reproductive system. As men age, the prostate undergoes hyperplasia, which can lead to urethral compression, resulting in voiding dysfunction and associated symptoms, as well as an increased risk of prost...