Adult Human Heart Extracellular Matrix Improves Human iPSC-CM Function via Mitochondrial and Metabolic Maturation

Medicine, Basic Medical Sciences, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
extracellular matrix   iPSC-derived cardiomyocyte   functional maturation   mitochondrial maturation   metabolic maturation   cell therapy  

1. Academic Background Cardiovascular diseases, especially myocardial infarction (MI), are among the leading causes of death and disability worldwide. After a myocardial infarction, up to one billion cardiomyocytes (CM) can be lost in just a few hours. However, adult myocardial tissue itself has extremely low regenerative capacity, which means the ...

Neonatal Apical Resection Preserves the Proliferative Capacity of Cardiomyocytes Throughout the Left Ventricle

Medicine, Basic Medical Sciences, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
apical resection   cardiomyocyte   cell-cycle   heart regeneration   heat shock protein   left ventricle   pig model  

I. Academic Background: The Cardiac Mystery Facing Regenerative Medicine Cardiovascular diseases, especially myocardial infarction (MI), are among the leading causes of death and disability worldwide due to heart damage. However, the adult mammalian heart has long been regarded as having essentially lost its endogenous regenerative ability, with th...

Renal Protective Effects of Extracellular Vesicle-Encapsulated Tumor Necrosis Factor-α-Induced Protein 6 Derived from Mesenchymal Stem Cells

Medicine, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
mesenchymal stem cells   inflammation   renal protection   extracellular vesicles   TNF-α-induced protein 6   M2 macrophage polarization   regulatory T cells  

I. Research Background and Academic Significance In recent years, the incidence of acute kidney injury (AKI) has been continuously rising worldwide. AKI not only leads to acute loss of renal function but is increasingly recognized as being closely related to the occurrence and progression of chronic kidney disease (CKD). Numerous epidemiological an...

METTL3 Promotes Osteogenesis by Regulating N6-Methyladenosine-Dependent Primary Processing of hsa-mir-4526

Medicine, Orthopedics, Basic Medical Sciences, Oral Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
METTL3   osteogenesis   N6-methyladenosine   miRNA processing   hsa-mir-4526   adipose stem cells   bone repair  

New Mechanism of m6A Methylation Promoting Osteogenic Differentiation of Adipose-Derived Stem Cells Revealed — Study Based on METTL3-Mediated Primary microRNA Splicing Regulation of hsa-mir-4526 1. Academic Background and Research Motivation Bone tissue engineering has emerged as a cutting-edge interdisciplinary research field due to rapid advances...

PDGFR Marks Distinct Mesenchymal and Pericyte Populations Within the Periosteum With Overlapping Cellular Features

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
periosteum   PDGFRβ   mesenchymal progenitor cells   pericytes   bone regeneration   single-cell RNA sequencing  

New Developments in Bone Regeneration: The Discovery of PDGFRβ-marked Distinct Mesenchymal and Pericyte Subpopulations in the Periosteum — Interpretation of “pdgfr marks distinct mesenchymal and pericyte populations within the periosteum with overlapping cellular features” 1. Research Background and Scientific Question The periosteum, a thin vascul...

A self-assembling surface layer flattens the cytokinetic furrow to aid cell division in an archaeon

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Biophysics, Microbiology,
self-assembly   surface layer   cell division   archaea   S-layer   membrane deformation   cell mechanics  

1. Academic Background Since the origin of life, living organisms have needed to construct effective barriers to protect their cells from external physical and chemical damage. In the realms of bacteria and archaea, the surface layer (S-layer) is a universally present and exquisitely structured two-dimensional protein lattice that substitutes for t...