Neural Stem Cell-Derived Extracellular Vesicles Alleviate Inflammatory Responses in a Mouse Model of Atopic Dermatitis

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
neural stem cells   extracellular vesicles   atopic dermatitis   inflammation   skin barrier   immune regulation   mouse model  

I. Academic Background and Research Motivation Atopic Dermatitis (AD) is a common chronic inflammatory skin disease characterized by eczematous lesions, intense itching, and impairment of skin barrier function. Its pathogenesis is highly complex, involving genetic susceptibility, epidermal barrier dysfunction, immune dysregulation, and environmenta...

Transcriptomic Analysis of the m6A Reader YTHDF2 in the Maintenance and Differentiation of Human Embryonic Stem Cells

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
m6A modification   YTHDF2   human embryonic stem cells   neuroectoderm differentiation   transcriptomics   ROBO1  

1. Research Background and Significance Over the past decade, the role of epigenetics in regulating cell fate decisions and disease development has become increasingly prominent. As a crucial part of epigenetic regulation, modifications at the RNA level—especially N6-methyladenosine (m6A)—have been confirmed to be widely present within eukaryotic m...

Stem Cell CNTF Promotes Olfactory Epithelial Neuroregeneration and Functional Recovery Following Injury

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry,
olfactory epithelium   stem cells   neuroregeneration   CNTF   inflammation   functional recovery  

Research Background and Academic Significance Olfaction is one of the most important ways for humans to sense the external environment, fundamentally relying on olfactory sensory neurons (OSNs) in the olfactory epithelium (OE). These neurons possess the ability to regenerate throughout life, primarily due to the presence of local basal stem cell po...

Fibroblast Activation Protein-α Interacts with CXCL12 to Inactivate Canonical Wnt Signaling and Regulate Osteoblast Differentiation

Medicine, Orthopedics, Basic Medical Sciences, Geriatrics, Endocrinology, Life Sciences, Cell Biology, Biochemistry,
fibroblast activation protein-α   CXCL12   Wnt/β-catenin pathway   osteoblast differentiation   adipocyte differentiation   osteoporosis   mesenchymal progenitor cells  

Academic Research Background With the global population aging rapidly, osteoporosis has gradually become a major disease threatening public health. Characterized by reduced bone mass and deterioration of bone microarchitecture, osteoporosis significantly increases the risk of fractures, severely impacts the quality of life of the elderly, and bring...

Neuropeptide Substance P Modulates Stem Cell Fate to Promote Wound Healing and Epidermal Stratification via Asymmetric Divisions

Medicine, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
Substance P   stem cell fate   wound healing   epidermal stratification   asymmetric division   sensory innervation   re-epithelialization  

Neuropeptide Substance P Regulates Stem Cell Division to Promote Wound Healing and Epidermal Stratification: An In-depth Interpretation of the Latest Study by Khalifa et al. Research Background and Scientific Questions Wound healing following skin injury has long been a central focus in both clinical and basic medical sciences. With aging, diabetes...

E3 Ligase TRIM63 Promotes Chondrogenic Differentiation of Mesenchymal Stem Cells by Catalyzing K27-Linked Cysteine Ubiquitination of MYH11

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
TRIM63   mesenchymal stem cells   chondrogenic differentiation   ubiquitination   MYH11   cartilage repair   osteoarthritis  

Research Progress on the Role of E3 Ubiquitin Ligase TRIM63 in Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells — An Interpretation of the Paper “E3 ligase TRIM63 promotes the chondrogenic differentiation of mesenchymal stem cells by catalyzing K27-linked cysteine ubiquitination of MYH11” 1. Academic Background and Research Motivati...