Quasi-spatial single-cell transcriptomics based on physical tissue properties defines early aging-associated niche in liver

Medicine, Hepatobiliary System, Basic Medical Sciences, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell sequencing   fibrotic niche   liver aging   senescent cells   spatial omics   physical tissue properties  

Redefining the Early-Aging Microenvironment in the Liver: Quasi-spatial Single-cell Transcriptomics Reveals Fibrotic Niche Formation and Cellular Heterogeneity Background and Research Motivation Aging is an inevitable process in life, with one of its most significant features being the accumulation of senescent cells within tissues and organs. Thes...

Single-cell and spatial transcriptomics reveal divergent microenvironments and progression signatures in early- and late-onset prostate cancer

Medicine, Basic Medical Sciences, Geriatrics, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell sequencing   spatial transcriptomics   prostate cancer   heterogeneity   tumor microenvironment   androgen response   tumor progression  

Background: Age-related Heterogeneity in Prostate Cancer and New Opportunities for Precision Medicine Prostate cancer (PCA) is the second most common malignancy and the fifth leading cause of cancer-related death among men worldwide. With the global aging population and the advancement of health screening, the age of onset for prostate cancer has b...

Large-scale plasma proteomic profiling unveils diagnostic biomarkers and pathways for Alzheimer's disease

Information Science, Artificial Intelligence, Medicine, Medical Laboratory Science, Geriatrics, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
Alzheimer's disease   proteomics   biomarkers   plasma proteins   disease diagnosis   pathway analysis  

1. Research Background and Academic Significance Alzheimer’s Disease (AD) is the most common form of dementia worldwide, accounting for about 60–80% of all dementia cases. The primary affected population is individuals over 65 years old, with characteristic pathological features including the deposition of amyloid-β plaques, neurofibrillary tangles...

Mitochondria-Enriched Hematopoietic Stem Cells Exhibit Elevated Self-Renewal Capabilities Within the Context of Aged Bone Marrow

Medicine, Basic Medical Sciences, Geriatrics, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
hematopoietic stem cells   mitochondria   self-renewal   aging   bone marrow   single-cell analysis   cell differentiation  

Mitochondria-Enriched Hematopoietic Stem Cells Reveal Enhanced Self-Renewal Activity in Aged Bone Marrow: In-Depth Analysis of the Latest Study in Nature Aging I. Academic Background and Research Significance Hematopoietic stem cells (HSCs) are the essential foundation underlying life-long production of blood and immune cells. However, with aging, ...

Retrotransposon-Derived Capsid Genes PNMA1 and PNMA4 Maintain Reproductive Capacity

Medicine, Obstetrics and Gynecology, Geriatrics, Endocrinology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics, Biophysics,
retrotransposon   capsid genes   PNMA1   PNMA4   reproductive capacity   gonadal tissue   evolution  

Mechanistic Study on How Retrotransposon-derived Capsid Genes PNMA1 and PNMA4 Maintain Reproductive Capacity — A New Research Review from Nature Aging I. Research Background and Scientific Significance Nearly half of the DNA in the human and mammalian genome is made up of retrotransposons, sequences that originally existed as “parasitic molecules” ...

Activation of AMPK by GLP-1R Agonists Mitigates Alzheimer-Related Phenotypes in Transgenic Mice

Medicine, Basic Medical Sciences, Geriatrics, Endocrinology, Neurology, Life Sciences, Cell Biology, Biochemistry,
GLP-1R agonists   AMPK   Alzheimer's disease   transgenic mice   neuroprotection   amyloid-beta   diabetes  

I. Research Background and Scientific Question Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide, with pathological features mainly including neuronal loss, neurofibrillary tangles, and senile plaques (mainly formed by amyloid-β [Aβ] deposition). According to statistics, the number of AD patients continues to rise each...