Activation of AMPK by GLP-1R Agonists Mitigates Alzheimer-Related Phenotypes in Transgenic Mice

Medicine, Basic Medical Sciences, Geriatrics, Endocrinology, Neurology, Life Sciences, Cell Biology, Biochemistry,
GLP-1R agonists   AMPK   Alzheimer's disease   transgenic mice   neuroprotection   amyloid-beta   diabetes  

I. Research Background and Scientific Question Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide, with pathological features mainly including neuronal loss, neurofibrillary tangles, and senile plaques (mainly formed by amyloid-β [Aβ] deposition). According to statistics, the number of AD patients continues to rise each...

Large-Scale Network Analysis of the Cerebrospinal Fluid Proteome Reveals Molecular Signatures of Frontotemporal Lobar Degeneration

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
frontotemporal lobar degeneration   cerebrospinal fluid   proteomics   network analysis   genetic mutations   biomarkers  

Analysis of Large-Scale Network Study of the CSF Proteome in FTLD — Unlocking Molecular Signatures of Neurodegenerative Diseases I. Academic Background and Motivation Frontotemporal Lobar Degeneration (FTLD) is one of the most common causes of early-onset dementia (under age 65), triggering a range of progressive behavioral, language, and even moto...

The Role of mRNA Metabolism Regulator Human Antigen R (HuR) in Age-Related Hearing Loss in Aged Mice

Medicine, Basic Medical Sciences, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
mRNA metabolism   HuR   age-related hearing loss   hair cells   auditory function   AAV gene therapy   cochlea  

mRNA Metabolism Regulator Human Antigen R (HuR) Regulates Age-Related Hearing Loss in Aged Mice — A Systematic Study of Molecular Pathological Mechanisms and Therapeutic Intervention 1. Academic Background and Scientific Questions Age-related hearing loss (ARHL), also known as presbycusis, is one of the most common sensory disorders in the global e...

Exosomes Derived from Exercise-Trained Mice Bone Marrow Mesenchymal Stem Cells Improve Wound Healing by Inhibiting Macrophage M1 Polarization

Medicine, Rheumatology and Immunology, Oral Sciences, Sports Medicine, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
bone marrow mesenchymal stem cells   exosome   treadmill exercise   macrophage polarization   M1   wound healing   inflammation  

I. Academic Background and Research Significance Wound healing is a highly complex physiological process that plays a crucial role in tissue regeneration, repair, and immune regulation. However, poor healing of chronic wounds is clinically widespread, severely impacting patients’ quality of life and increasing medical and socioeconomic burdens. The...

Contribution of Cytokeratin 19-Expressing Cells towards Islet Regeneration Induced by Multipotent Stromal Cell Secreted Proteins

Medicine, Basic Medical Sciences, Endocrinology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
Cytokeratin 19   Multipotent stromal cells   Islet regeneration   Diabetes   Lineage tracing   Ductal endocrine progenitor cells  

Background Introduction Diabetes, especially type 1 diabetes (T1D), is a chronic autoimmune disease characterized by the persistent destruction of pancreatic β cells by the immune system, resulting in the loss of the ability to regulate blood glucose. Patients with type 1 diabetes typically require lifelong insulin injections; however, long-term in...

Neural Stem Cell-Derived Extracellular Vesicles Alleviate Inflammatory Responses in a Mouse Model of Atopic Dermatitis

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
neural stem cells   extracellular vesicles   atopic dermatitis   inflammation   skin barrier   immune regulation   mouse model  

I. Academic Background and Research Motivation Atopic Dermatitis (AD) is a common chronic inflammatory skin disease characterized by eczematous lesions, intense itching, and impairment of skin barrier function. Its pathogenesis is highly complex, involving genetic susceptibility, epidermal barrier dysfunction, immune dysregulation, and environmenta...