Communication Between Cancer Cell Subtypes by Exosomes Contributes to Nasopharyngeal Carcinoma Metastasis and Poor Prognosis

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
cell heterogeneity   cell communication   exosomes   metastasis   nasopharyngeal carcinoma  

Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial lining of the nasopharynx, characterized by a distinct geographical distribution, particularly with high incidence rates in Southeast Asia and Southern China. Despite significant progress in NPC treatment in recent years, the prognosis for patients remains poor, esp...

Suppression of Myd88 Disturbs Gut Microbiota and Activates the NLR Pathway and Hence Fails to Ameliorate DSS-Induced Colitis

Medicine, Gastroenterology, Life Sciences, Immunology,
Myd88   gut microbiota   NLR pathway   colitis   inflammatory bowel disease  

Inflammatory Bowel Disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract, primarily including Ulcerative Colitis (UC) and Crohn’s Disease (CD). In recent years, the incidence of IBD has been on the rise globally, placing a significant burden on healthcare systems. Although it is widely accepted that IBD is associ...

Hydrogen Gas and the Gut Microbiota as Potential Biomarkers for the Development of Experimental Colitis in Mice

Medicine, Gastroenterology, Life Sciences, Immunology, Microbiology,
gut microbiota   hydrogen gas   experimental colitis   inflammatory bowel disease   biomarker  

Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition that primarily includes Ulcerative Colitis (UC) and Crohn’s Disease (CD). The incidence of IBD has been increasing globally, imposing significant health and economic burdens on patients and society. Currently, the diagnosis of IBD relies mainly on endoscopy, but this method is exp...

Interleukin-12p40 Deficiency Attenuates Myocardial Ferroptosis in Doxorubicin-Induced Chronic Cardiomyopathy by Inhibiting Th17 Differentiation and Interleukin-17A Production

Medicine, Rheumatology and Immunology, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
Interleukin-12p40   Doxorubicin-induced cardiotoxicity   Ferroptosis   Inflammation   Adaptive immunity   T lymphocyte differentiation  

Academic Background Doxorubicin (Dox) is an anthracycline drug widely used in the treatment of tumors, but it exhibits dose-dependent cardiotoxicity, potentially leading to cardiomyopathy and heart failure. Despite its significant anticancer effects, the cardiotoxicity of Dox limits its clinical application. Currently, Dexrazoxane is the only FDA-a...

EPICPred: Predicting Phenotypes Driven by Epitope-Binding TCRs Using Attention-Based Multiple Instance Learning

Information Science, Computer Science, Artificial Intelligence, Medicine, Life Sciences, Bioengineering, Immunology,
epitope-binding TCRs   multiple instance learning   phenotype prediction   cancer   COVID-19  

T-cell receptors (TCRs) play a crucial role in the adaptive immune system by recognizing pathogens through binding to specific antigen epitopes. Understanding the interactions between TCRs and epitopes is essential for uncovering the biological mechanisms of immune responses and developing T cell-mediated immunotherapies. However, although the impo...

ImmunoTar—Integrative Prioritization of Cell Surface Targets for Cancer Immunotherapy

Information Science, Computer Science, Artificial Intelligence, Medicine, Oncology, Life Sciences, Immunology,
cancer immunotherapy   cell surface targets   RNA sequencing   proteomics   computational tool  

Cancer remains one of the leading causes of death globally. Despite significant advancements in immunotherapy in recent years, such as the successful application of chimeric antigen receptor T-cell (CAR-T) therapy and antibody-drug conjugates (ADCs), the effective identification of cancer-specific surface protein targets remains a major challenge i...