Breast cancer is one of the most common malignant tumors among women worldwide, with a complex pathogenesis involving multiple gene mutations and signaling pathway abnormalities. Homologous Recombination Deficiency (HRD) is a significant molecular characteristic in breast cancer, closely related to patients’ sensitivity to PARP inhibitor (PARPi) th...

Academic Background Ulcerative Colitis (UC) is a chronic inflammatory bowel disease characterized by recurrent inflammation and ulceration of the colonic mucosa. Current treatments for UC primarily rely on immunosuppressive drugs, such as corticosteroids, immunomodulators, and biologics. However, the immunosuppressive properties of these drugs incr...

Infantile Hemangioma (IH) is the most common benign vascular tumor in children, with an incidence rate of approximately 4%-10%. Although most IH cases resolve spontaneously, some cases may lead to permanent pigmentation, fibrous tissue accumulation, and scarring, affecting the appearance and quality of life of children. Additionally, certain IH cas...

Colorectal Cancer (CRC) is one of the most prevalent malignancies globally, with its prognosis closely related to immune responses within the tumor microenvironment. In recent years, Tertiary Lymphoid Structures (TLS), as an essential component of the tumor microenvironment, have been associated with favorable patient outcomes. TLS are aggregates o...

Academic Background Ulcerative Colitis (UC) is a chronic inflammatory bowel disease often accompanied by various extraintestinal complications, among which pulmonary infections are particularly severe. Although previous studies have indicated interactions between the intestinal and pulmonary immune systems, the specific mechanisms involving neutrop...

Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial lining of the nasopharynx, characterized by a distinct geographical distribution, particularly with high incidence rates in Southeast Asia and Southern China. Despite significant progress in NPC treatment in recent years, the prognosis for patients remains poor, esp...