Determining Risk Features for Medulloblastoma in the Molecular Era

Medicine, Pediatrics, Neurology, Oncology,
medulloblastoma   molecular classification   risk stratification   radiation therapy   methylation profiling   chemotherapy   survival rate  

Advances in Risk Stratification and Treatment Strategies for Medulloblastoma Background Medulloblastoma is a common malignant brain tumor in children, with significant differences in treatment and prognosis depending on its molecular subtypes. In recent years, advances in molecular biology have revealed that medulloblastoma can be further divided i...

Distribution and Outcomes of Paediatric Anaesthesia Services in Sweden: An Epidemiological Study

Medicine, Pediatrics, Anesthesiology,
paediatric anaesthesia   epidemiology   Sweden   complications   mortality   centralisation   neonates  

Distribution and Outcomes of Paediatric Anaesthesia Services in Sweden: An Epidemiological Study Academic Background In recent years, there has been a growing trend towards the centralization of perioperative care for children globally, particularly in European countries. This trend is primarily driven by research findings from professional organiz...

International Multi-Institutional External Validation of Preoperative Risk Scores for 30-Day In-Hospital Mortality in Paediatric Patients

Medicine, Pediatrics, Anesthesiology,
paediatric anaesthesia   risk prediction   external validation   mortality   preoperative scoring  

External Validation of Preoperative Risk Scores for 30-Day In-Hospital Mortality in Pediatric Patients Academic Background Although the perioperative mortality rate in pediatric patients is low (<0.5%), it remains a significant issue in clinical practice. Traditional risk assessment tools, such as the American Society of Anesthesiologists (ASA) Phy...

Parent-Targeted Oral Health Text Messaging for Underserved Children Attending Pediatric Clinics: A Randomized Clinical Trial

Medicine, Pediatrics, Oral Sciences,
oral health   text messaging   randomized clinical trial   low-income families   childhood caries   preventive dental behaviors   health disparities  

Academic Paper Report Caries is one of the most common chronic diseases in children, with significant health disparities across racial, ethnic, and income groups. Despite the availability of effective preventive measures, children from low-income and minority ethnic groups continue to face higher risks of caries. The American Academy of Pediatrics ...

Emapalumab Therapy for Hemophagocytic Lymphohistiocytosis Before Reduced-Intensity Transplantation Improves Chimerism

Medicine, Pediatrics, Hematology, Life Sciences, Immunology,
Hemophagocytic Lymphohistiocytosis   Chimerism   Reduced-Intensity Transplantation   Emapalumab   Intervention-Free Survival  

Research Report on Pre-HCT Emapalumab Therapy Improving Donor Chimerism in Children with HLH Background and Objective of the Study Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening immune disorder caused by pathological immune activation. The primary mechanism involves the functional deficiency of cytotoxic activity in natural killer (...