Whole Lung Irradiation in Rhabdomyosarcoma with Lung Metastases: A Report from the Soft Tissue Sarcoma Committee of the Children’s Oncology Group

Efficacy of Whole Lung Irradiation in Rhabdomyosarcoma with Lung Metastases Academic Background Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma in children. Despite advancements in treatment, the prognosis for patients with metastatic RMS remains poor, especially for those with lung metastases, whose survival rates are significantly lower th...

The Respiratory Microbiome is Linked to the Severity of RSV Infections and the Persistence of Symptoms in Children

The Respiratory Microbiome is Linked to the Severity of RSV Infections and the Persistence of Symptoms in Children Academic Background Respiratory Syncytial Virus (RSV) is a leading cause of respiratory infections and hospitalizations in infants. While known risk factors for severe infections include preterm birth, congenital heart disease, and bro...

The Neonatal Gut Microbiota: A Role in the Encephalopathy of Prematurity

The Neonatal Gut Microbiota: A Role in the Encephalopathy of Prematurity

The Role of the Neonatal Gut Microbiota in the Encephalopathy of Prematurity: A Comprehensive Study Academic Background Premature birth (defined as birth before 37 weeks of gestation) is a common issue globally, affecting approximately 10% of pregnancies. Preterm infants are at risk of abnormal brain development, known as Encephalopathy of Prematur...

Long-term Neuropsychological Trajectories in Children with Epilepsy: Does Surgery Halt Decline?

Long-term Neuropsychological Trajectories in Pediatric Epilepsy Patients: Can Surgery Prevent Decline? Patients with long-term drug-resistant epilepsy (DRE) often face severe neuropsychological functional impairments, especially in children, which can significantly impact their academic performance, social relationships, and future employment oppor...

The Clinical and Genetic Spectrum of Inherited Glycosylphosphatidylinositol Deficiency Disorders

Clinical and Genetic Spectrum Study of Inherited Glycosylphosphatidylinositol Deficiency Disorders (IGDs) Background Introduction The glycosylphosphatidylinositol (GPI) anchoring pathway is crucial for post-translational modification of many important proteins in eukaryotes, which are fundamental for cell signaling and early human neurogenesis and ...