Single-Cell Analysis Reveals Alterations Between the Aged and Young Mice Prostates

Medicine, Urology, Life Sciences, Cell Biology, Immunology,
Single-cell RNA sequencing   Prostate aging   Cellular heterogeneity   Gene expression   Mouse model  

Single-Cell Analysis Reveals Differences Between Aged and Young Mouse Prostates Academic Background The prostate is a vital component of the male reproductive system. As men age, the prostate undergoes hyperplasia, which can lead to urethral compression, resulting in voiding dysfunction and associated symptoms, as well as an increased risk of prost...

Validation of a Prognostic Blood-Based Sphingolipid Panel for Men with Localized Prostate Cancer Followed on Active Surveillance

Medicine, Urology, Oncology,
sphingolipids   prostate cancer   active surveillance   biomarkers   risk stratification  

Study on a Prognostic Blood-Based Sphingolipid Panel for Men with Localized Prostate Cancer on Active Surveillance Academic Background Prostate cancer is one of the most common cancers among men globally, particularly for those with low- and intermediate-risk prostate cancer, where active surveillance (AS) has become the preferred management strate...

Efficacy and Safety of Darolutamide in Combination with Androgen-Deprivation Therapy in Patients with Metastatic Hormone-Sensitive Prostate Cancer

Medicine, Urology, Oncology,
Darolutamide   Androgen-Deprivation Therapy   Metastatic Hormone-Sensitive Prostate Cancer   Radiological Progression-Free Survival   Safety  

Darolutamide in Combination with Androgen-Deprivation Therapy in Patients with Metastatic Hormone-Sensitive Prostate Cancer from the Phase III ARANOTE Trial Academic Background Metastatic hormone-sensitive prostate cancer (mHSPC) is a common type of prostate cancer. Patients typically respond to androgen-deprivation therapy (ADT) for a period of ti...

MRI-Directed Micro-US–Guided Transperineal Focal Laser Ablation for Localized Prostate Cancer: A 1-Year Follow-Up Study

Medicine, Urology, Medical Imaging, Oncology,
prostate cancer   focal laser ablation   micro-US   MRI-guided   transperineal   recurrence rate   functional preservation  

MRI-Guided Micro-US Transperineal Focal Laser Ablation for Localized Prostate Cancer: A 1-Year Follow-Up Study Academic Background Prostate cancer (PCA) is one of the most common malignancies among men worldwide. With the widespread adoption of prostate-specific antigen (PSA) screening, the diagnosis of low-risk prostate cancer has significantly in...

NACVI-RADS Scores for Assessing Muscle-Invasive Bladder Cancer Response to Neoadjuvant Immunotherapy with Multiparametric MRI

Medicine, Urology, Medical Imaging, Oncology,
Muscle-Invasive Bladder Cancer   Neoadjuvant Immunotherapy   Multiparametric MRI   NACVI-RADS Scores   Pathologic Complete Response  

Academic Background Muscle-invasive bladder cancer (MIBC) is a highly aggressive malignancy. The standard treatment typically involves cisplatin-based neoadjuvant chemotherapy (NAC) or immunotherapy, followed by radical cystectomy (RC) and bilateral pelvic lymph node dissection. However, radical cystectomy significantly impacts patients’ quality of...