PSMA-PET/CT Findings in Patients with High-Risk Biochemically Recurrent Prostate Cancer with No Metastatic Disease by Conventional Imaging

Medicine, Urology, Medical Imaging, Oncology,
prostate cancer   PSMA-PET/CT   biochemical recurrence   high-risk   imaging   metastasis   treatment guidance  

Academic Background Prostate cancer is one of the most common cancers in men worldwide, particularly in Western countries. Despite advances in early diagnosis and treatment significantly improving survival rates, cancer recurrence remains a major clinical challenge. This is particularly true for patients with high-risk nonmetastatic hormone-sensiti...

Prevalence and Clinical Significance of Claudin-3 Expression in Cancer: A Tissue Microarray Study on 14,966 Tumor Samples

Medicine, Obstetrics and Gynecology, Urology, Nephrology, Oncology,
Claudin-3   tissue microarray   cancer   renal cell carcinoma   biomarker  

Prevalence and Clinical Significance of Claudin-3 Expression in Cancer: A Tissue Microarray Study on 14,966 Tumor Samples Academic Background Claudin-3 (Cldn3) is a member of the Claudin family, involved in the formation of tight junctions (TJs), which regulate intercellular permeability. TJs play a crucial role in maintaining the barrier function ...

Advanced Single-Cell and Spatial Analysis with High-Multiplex Characterization of Circulating Tumor Cells and Tumor Tissue in Prostate Cancer: Unveiling Resistance Mechanisms with the CODuco In Situ Assay

Medicine, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Circulating Tumor Cells (CTCs)   Metastatic Prostate Cancer   Multiplex Padlock Probe In Situ Hybridization   Single-Cell Gene Expression   Liquid Biopsy   Spatial Transcriptomics   Neuroendocrine Transdifferentiation  

Research Report on the Academic Paper Title: Advanced Single-Cell and Spatial Analysis with High-Multiplex Characterization of Circulating Tumor Cells and Tumor Tissue in Prostate Cancer: Unveiling Resistance Mechanisms with the CODuco In Situ Assay Authors: Lilli Bonstingl et al. Journal: Biomarker Research (2024) 12:140 DOI: 10.1186/s40364-024-00...

GDF15 Propeptide Promotes Bone Metastasis of Castration-Resistant Prostate Cancer by Augmenting the Bone Microenvironment

Medicine, Urology, Oncology, Life Sciences, Biochemistry,
Castration-Resistant Prostate Cancer   Bone Metastasis   GDF15   Biomarker   Bone Microenvironment  

Research Objective This study aims to identify specific proteins secreted by prostate cancer cells through comprehensive proteomic analysis and explore their role in bone metastasis, with the goal of discovering blood biomarkers that can improve the prognosis of patients with metastatic castration-resistant prostate cancer (mCRPC). Research Team an...

Exosomal PSM-E Inhibits Macrophage M2 Polarization to Suppress Prostate Cancer Metastasis Through the RACK1 Signaling Axis

Medicine, Urology, Oncology,
prostate cancer   exosomes   macrophage polarization   RACK1 signaling pathway   tumor microenvironment  

Exosomal PSM-E Inhibits Macrophage M2 Polarization to Suppress Prostate Cancer Metastasis via the RACK1 Signaling Axis Academic Background Prostate cancer (PCA) is a prevalent cancer among men and the second leading cause of cancer-related deaths. While early-stage prostate cancer can be treated with surgery or radiotherapy, approximately one-third...