Use of Coagulation Factor Concentrates and Blood Transfusion in Cardiac Surgery: A Retrospective Cohort Study of Adults with Hereditary and Acquired Bleeding Disorders

Medicine, Anesthesiology, Hematology, Cardiovascular System,
bleeding disorder   cardiac surgery   coagulation factor concentrate   healthcare cost   perioperative bleeding   perioperative complications   transfusion  

Use of Coagulation Factor Concentrates and Blood Transfusion in Cardiac Surgery: A Retrospective Cohort Study of Adults with Hereditary and Acquired Bleeding Disorders Academic Background Cardiac surgery is one of the high-risk procedures, especially for patients with bleeding disorders, as it significantly increases the risk of perioperative bleed...

Saliva of Persons with Hemophilia A Triggers Coagulation via Extrinsic Tenase Complexes

Medicine, Hematology,
Hemophilia A   Extrinsic Tenase Complex   Saliva   Coagulation   FVII Deficiency  

Extrinsic Tenase Complexes in Human Saliva Trigger Coagulation in Patients with Severe Hemophilia A Background Introduction Hemophilia A is a hereditary bleeding disorder caused by a deficiency or defect in clotting factor VIII (FVIII), inherited in an X-linked recessive pattern. Patients with severe hemophilia A often experience recurrent joint bl...

GSDME-mediated pyroptosis contributes to chemotherapy-induced platelet hyperactivity and thrombotic potential

Medicine, Hematology, Life Sciences, Cell Biology, Biochemistry,
platelets   pyroptosis   chemotherapy   thrombosis   GSDME   caspase-3   membrane pore formation  

Background Introduction Chemotherapy has long been a cornerstone of cancer treatment but is accompanied by significant side effects. Among cancer patients receiving platinum-based chemotherapy drugs (e.g., cisplatin), the incidence of thromboembolic events significantly increases, including pulmonary embolism, cerebrovascular incidents, angina, and...

Impact of Soluble BCMA and Non–T-Cell Factors on Refractoriness to BCMA-Targeting T-Cell Engagers in Multiple Myeloma

Medicine, Hematology, Oncology, Life Sciences, Immunology,
Soluble BCMA   Multiple Myeloma   T-Cell Engagers   Refractoriness   Tumor Burden   Surface Antigen Density   Therapeutic Optimization  

The Impact of Soluble B-Cell Maturation Antigen (sBCMA) on Multiple Myeloma Therapy: Interpreting the Latest Research Findings In recent years, cell-based immunotherapies have demonstrated enormous promise in the treatment of multiple myeloma (MM). Among these, BCMA-targeting T-cell engagers (TCEs) and chimeric antigen receptor (CAR) T-cell therapi...

Emapalumab Therapy for Hemophagocytic Lymphohistiocytosis Before Reduced-Intensity Transplantation Improves Chimerism

Medicine, Pediatrics, Hematology, Life Sciences, Immunology,
Hemophagocytic Lymphohistiocytosis   Chimerism   Reduced-Intensity Transplantation   Emapalumab   Intervention-Free Survival  

Research Report on Pre-HCT Emapalumab Therapy Improving Donor Chimerism in Children with HLH Background and Objective of the Study Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening immune disorder caused by pathological immune activation. The primary mechanism involves the functional deficiency of cytotoxic activity in natural killer (...

Prognostic Impact of Cytogenetic Abnormalities Detected by FISH in AL Amyloidosis with Daratumumab-Based Frontline Therapy

Medicine, Hematology, Oncology, Life Sciences, Immunology,
AL amyloidosis   daratumumab   cytogenetic abnormalities   FISH   prognosis   frontline therapy   hematologic response  

Review of the Impact of FISH-Detected Cytogenetic Abnormalities on Prognosis in AL Amyloidosis in the Era of Daratumumab Therapy Background Immunoglobulin light chain (AL) amyloidosis is a rare disease characterized by organ dysfunction caused by the deposition of light chain proteins secreted by abnormal plasma cells. However, the heterogeneous cl...