Inhibition of Fatty Acid Uptake by TGR5 Prevents Diabetic Cardiomyopathy

Medicine, Endocrinology, Cardiovascular System, Life Sciences, Biochemistry,
Diabetic Cardiomyopathy   Fatty Acid Uptake   TGR5   Lipid Metabolism   Cardioprotection   Fatty Acid Transport   Metabolic Regulation  

Preventing Diabetic Cardiomyopathy through Suppressing TGR5-Mediated Fatty Acid Uptake Background and Problem Statement Diabetic Cardiomyopathy (DBCM) is a severe complication frequently faced by diabetic patients, characterized by lipid accumulation in the myocardium and cardiac dysfunction. Bile acid metabolism plays a crucial role in cardiovascu...

Characterization, number, and spatial organization of nerve fibers in the human cervical vagus nerve and its superior cardiac branch

Medicine, Basic Medical Sciences, Neurology, Cardiovascular System, Life Sciences, Bioengineering, Biophysics,
human vagus nerve   superior cardiac branch   vagal motor fibers   vagal sensory fibers   sympathetic fibers   immunofluorescence   vagus nerve stimulation  

Characteristics, Quantity, and Spatial Distribution of Human Cervical Vagus Nerve and its Cardiac Superior Branch Nerve Fibers Introduction In modern medicine, Vagus Nerve Stimulation (VNS) is widely used to treat various diseases such as epilepsy, obesity, depression, and heart diseases. Although the overall Vagus nerve stimulation method has prov...

Heart Failure Promotes Multimorbidity Through Innate Immune Memory

Heart Failure Promotes Multimorbidity Through Innate Immune Memory

Medicine, Oncology, Cardiovascular System, Life Sciences, Immunology,
heart failure   multimorbidity   innate immune memory   hematopoietic stem cells   inflammation   cardiac disease  

Heart Failure Promotes Multimorbidity through Innate Immune Memory Research Background Despite significant medical advances, the mortality rate of heart failure (HF) remains high, necessitating new therapeutic targets. HF patients often experience acute decompensation and develop comorbidities such as chronic kidney disease and frailty syndrome. Th...

3D/2D Vessel Registration Based on Monte Carlo Tree Search and Manifold Regularization

3D/2D Vessel Registration Based on Monte Carlo Tree Search and Manifold Regularization

Mathematics, Medicine, Medical Imaging, Cardiovascular System, Life Sciences, Bioengineering,
3D/2D registration   vessel graph matching   Monte Carlo tree search   manifold regularization   rigid registration   nonrigid registration  

Research on 3D/2D Vascular Registration Based on Monte Carlo Tree Search and Manifold Regularization In interventional vascular surgery, enhanced intraoperative real-time imaging technology can compensate for the shortcomings of DSA navigation, such as the lack of depth information and excessive use of toxic contrast agents, by projecting preoperat...

Heart Sound Abnormality Detection from Multi-Institutional Collaboration: Introducing a Federated Learning Framework

Heart Sound Abnormality Detection from Multi-Institutional Collaboration: Introducing a Federated Learning Framework

Information Science, Artificial Intelligence, Medicine, Cardiovascular System,
Heart Sound Abnormality   Multi-Institutional Collaboration   Federated Learning   Privacy Protection   Deep Learning  

Academic Background Cardiovascular diseases (CVDs) have become one of the leading causes of death, particularly within the elderly population, making cardiovascular health a pressing societal concern. Early screening, diagnosis, and prognosis management are crucial for preventing hospitalizations. Heart sound signals carry rich physiological and pa...

T-Wave Peak-to-End Changes Quantified by Time-Warping Predicts Ventricular Fibrillation in a Porcine Myocardial Infarction Model

Medicine, Basic Medical Sciences, Cardiovascular System, Life Sciences, Biophysics,
time warping   T-wave morphology   ventricular fibrillation   ischemia   T-peak-to-T-end interval   repolarization  

Prediction of Ventricular Fibrillation in Myocardial Infarction Model in Pigs Based on T-peak-to-T-end Interval Variation Using Time Warping Technique Background Introduction Source of the Paper Sudden Cardiac Death (SCD) is a leading cause of mortality worldwide, with one of its primary pathogenic mechanisms being Ventricular Fibrillation (VF), es...