LGALS9B stabilizes EEF1D protein and activates the PI3K/AKT signaling pathway to promote gastric cancer occurrence and metastasis

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
gastric cancer   LGALS9B   EEF1D   PI3K/AKT signaling pathway   tumor metastasis   cell proliferation   molecular mechanism  

lgals9b Stabilizes eef1d Protein and Activates the PI3K/AKT Signaling Pathway to Promote Gastric Cancer Occurrence and Metastasis Academic Background Gastric cancer ranks as the fifth most prevalent cancer globally, with over one million new cases diagnosed annually. Due to late detection, it exhibits a high mortality rate and is the fourth leading...

Metabolic Rewiring Controlled by HIF-1α Tunes IgA-Producing B-Cell Differentiation and Intestinal Inflammation

Medicine, Rheumatology and Immunology, Gastroenterology, Life Sciences, Cell Biology, Biochemistry, Immunology,
hypoxia   B cells   IgA   HIF-1α   intestinal inflammation   metabolic rewiring   epigenetics  

Metabolic Rewiring Controlled by HIF-1α Tunes IgA-Producing B-Cell Differentiation and Intestinal Inflammation Background Introduction Germinal centers (GC) are critical sites for the clonal expansion of immune B cells and the affinity maturation of antibodies, as well as the occurrence of antibody class switching. Within the GC, B cells undergo so...

The Antitumor Activity of TGFβ-Specific T Cells is Dependent on IL-6 Signaling

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Immunology,
TGFβ   IL-6   immunosuppression   tumor microenvironment   vaccines  

Review of the Study on the Relationship Between IL-6 Signaling and the Anti-Tumor Activity of TGFβ-Specific T Cells Background and Significance of the Study Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a critical role in inflammation and hematopoiesis. However, its role in the immune system is context-dependent. While it has pro-inflam...

Spatial Transcriptome Profiling Identifies DTX3L and BST2 as Key Biomarkers in Esophageal Squamous Cell Carcinoma Tumorigenesis

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Esophageal squamous cell carcinoma   Tumorigenesis   Spatial transcriptome   Single-cell transcriptome   Tumor-associated macrophage   Polarization   Spatial biomarker   Functional studies  

Digital Spatial Transcriptomics Highlights DTX3L and BST2 as Crucial Biomarkers in Esophageal Squamous Cell Carcinoma Tumorigenesis Background and Research Question Esophageal cancer (EC) remains a globally prevalent malignant disease with high incidence and mortality rates. Esophageal squamous cell carcinoma (ESCC), the most common histological su...

Structural Variant Allelic Heterogeneity in MECP2 Duplication Syndrome Provides Insight into Clinical Severity and Variability of Disease Expression

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
MECP2 duplication syndrome   structural variant   allelic heterogeneity   clinical severity   disease expression   genomic rearrangement   phenotypic traits  

Study of Structural Variation in MECP2 Duplication Syndrome and Its Phenotypic Variability Academic Background MECP2 Duplication Syndrome (MRXSL) is an X-linked genomic disorder primarily caused by an increase in the copy number of the MECP2 gene on the X chromosome. This condition predominantly affects males, and its clinical features vary widely,...

Integrated Analyses of Multi-Omic Data Reveal Metabolic Vulnerability as a Novel Therapeutic Target in Lung Cancer Brain Metastases

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Lung cancer brain metastases   Metabolic vulnerability   Tumor immune microenvironment   Multi-omic analysis   Mitochondrial metabolism  

Report on the Multi-Omics Study of Lung Cancer Brain Metastases (LC-BMs) Academic Background Lung cancer is one of the most prevalent and deadly cancers worldwide. Lung cancer brain metastases (LC-BMs) are a common complication in patients with lung cancer and are associated with poor prognosis. Despite advances in lung cancer therapies, the standa...