Layer-Specific Anatomical and Physiological Features of the Retina’s Neurovascular Unit

Medicine, Neurology, Ophthalmology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
retina   neurovascular unit   Müller glia   calcium signaling   retinitis pigmentosa  

Academic Report on the Study of Layer-Specific Anatomical and Physiological Characteristics of the Retinal Neurovascular Unit Background and Problem Statement Retinal processing, similar to all neural computations, is metabolically expensive and involves the dynamic regulation of blood flow, known as neurovascular coupling (NVC). The retina is supp...

Separate Sites of Action for Cry1 and Phot1 Blue-Light Receptors in the Arabidopsis Hypocotyl

Life Sciences, Cell Biology, Biochemistry, Botany,
blue-light receptors   Arabidopsis   hypocotyl   cell expansion   photomorphogenesis   growth kinematics   plant photoreception  

Report on the Paper “Separate Sites of Action for Cry1 and Phot1 Blue-Light Receptors in the Arabidopsis Hypocotyl” Background and Motivation Plants rely on the rapid elongation of the hypocotyl to overcome the resistance of the soil surface and access light environments for establishing autotrophic photosynthesis. Upon exposure to blue light, the ...

Metabolite-Level Regulation of Enzymatic Activity Controls Awakening of Cyanobacteria from Metabolic Dormancy

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Microbiology,
cyanobacteria   metabolic dormancy   enzyme activity   metabolite regulation   resuscitation mechanism  

Highlights of the Study: Metabolite-Level Regulation of Cyanobacteria Awakening from Dormancy Study Title: “Metabolite-level regulation of enzymatic activity controls awakening of cyanobacteria from metabolic dormancy” Published in Current Biology (January 6, 2025), this study, led by Sofía Doello, involves researchers from the University of Tübing...

Impaired Pheromone Detection and Abnormal Sexual Behavior in Female Mice Deficient for AncV1R

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry,
pheromone   female mice   AncV1R   sexual behavior   stress response   neural activity   mating behavior  

Report on the Study of the Impact of ANCV1R Gene Deficiency on Pheromone Detection and Sexual Behavior in Mice Background Introduction In mammals, pheromones are crucial chemical signals that regulate social and sexual behaviors. Pheromone detection is mediated by the vomeronasal organ (VNO), which uses vomeronasal sensory neurons (VSNs) to recogni...

GSDME-mediated pyroptosis contributes to chemotherapy-induced platelet hyperactivity and thrombotic potential

Medicine, Hematology, Life Sciences, Cell Biology, Biochemistry,
platelets   pyroptosis   chemotherapy   thrombosis   GSDME   caspase-3   membrane pore formation  

Background Introduction Chemotherapy has long been a cornerstone of cancer treatment but is accompanied by significant side effects. Among cancer patients receiving platinum-based chemotherapy drugs (e.g., cisplatin), the incidence of thromboembolic events significantly increases, including pulmonary embolism, cerebrovascular incidents, angina, and...

Focal Deletions of a Promoter Tether Activate the IRX3 Oncogene in T-Cell Acute Lymphoblastic Leukemia

Medicine, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
T-cell acute lymphoblastic leukemia   FTO gene   IRX3 oncogene   enhancer hijacking   CTCF binding site   noncoding genome   tumor suppressor mechanism  

Stage-specific Chromosomal Deletions Activate the IRX3 Oncogene in T-cell Acute Lymphoblastic Leukemia In the field of cancer research, understanding regulatory mechanisms of the noncoding genome remains a key focus, especially concerning how oncogenes can be aberrantly activated through non-canonical regulatory pathways. This paper, authored by Su...