Mapping In Silico Genetic Networks of the KMT2D Tumour Suppressor Gene to Uncover Novel Functional Associations and Cancer Cell Vulnerabilities

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
tumour suppressor genes   KMT2D   genetic networks   synthetic lethality   WRN inhibitors  

Academic Background and Problem Statement Loss-of-Function (LOF) mutations in Tumor Suppressor Genes (TSGs) are prevalent in cancer. However, therapeutic strategies directly targeting these mutations are challenging due to the loss or reduction of encoded protein function, which in normal states plays a role in inhibiting aberrant cell proliferatio...

Ubiquitin Regulatory X (UBX) Domain-Containing Protein 6 is Essential for Autophagy Induction and Inflammation Control in Macrophages

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology,
UBXN6   sepsis   inflammation   autophagy   immunosuppression  

Critical Role of UBXN6 in Autophagy Induction and Inflammation Control in Macrophages Background The innate immune system serves as the first line of defense against pathogen invasion and inflammatory responses. Monocytes and macrophages, as key cell types in the innate immune system, play critical roles during infection and inflammation. However, ...

Alternative mRNA Polyadenylation Regulates Macrophage Hyperactivation via the Autophagy Pathway

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology,
alternative polyadenylation   NUDT21   macrophage   autophagy   inflammation  

NUDT21 Regulates Macrophage Hyperactivation via the Autophagy Pathway Academic Background The inflammatory response is a critical component of the body’s immune defense, facilitating pathogen clearance and tissue repair. However, dysregulation of the inflammatory response can lead to chronic inflammatory diseases such as inflammatory bowel disease ...

Integrated Single-Cell Analysis Reveals Distinct Epigenetic-Regulated Cancer Cell States and a Heterogeneity-Guided Core Signature in Tamoxifen-Resistant Breast Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Genetics,
single-cell analysis   epigenetic regulation   breast cancer heterogeneity   tamoxifen resistance   core signature   tumor microenvironment   BMP7  

Integrated Single-Cell Analysis Reveals Distinct Epigenetic-Regulated Cancer Cell States and a Heterogeneity-Guided Core Signature in Tamoxifen-Resistant Breast Cancer Academic Background Breast cancer is one of the most common cancers in women, and endocrine therapy (e.g., tamoxifen) is the standard treatment for estrogen receptor α (ER)-positive ...

Days-Old Zebrafish Rapidly Learn to Recognize Threatening Agents Through Noradrenergic and Forebrain Circuits

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
zebrafish   learning   noradrenergic   forebrain circuits   threat recognition   neural mechanisms   young animals  

This study explores the necessity of quickly recognizing and avoiding predators in the natural environment, which is crucial for juvenile animals due to their increased vulnerability to predators. However, it remains unclear whether neonatal vertebrates can rapidly acquire such skills and the underlying neural mechanisms. Zebrafish, a widely used m...

Layer-Specific Anatomical and Physiological Features of the Retina’s Neurovascular Unit

Medicine, Neurology, Ophthalmology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
retina   neurovascular unit   Müller glia   calcium signaling   retinitis pigmentosa  

Academic Report on the Study of Layer-Specific Anatomical and Physiological Characteristics of the Retinal Neurovascular Unit Background and Problem Statement Retinal processing, similar to all neural computations, is metabolically expensive and involves the dynamic regulation of blood flow, known as neurovascular coupling (NVC). The retina is supp...