Focal Deletions of a Promoter Tether Activate the IRX3 Oncogene in T-Cell Acute Lymphoblastic Leukemia

Medicine, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
T-cell acute lymphoblastic leukemia   FTO gene   IRX3 oncogene   enhancer hijacking   CTCF binding site   noncoding genome   tumor suppressor mechanism  

Stage-specific Chromosomal Deletions Activate the IRX3 Oncogene in T-cell Acute Lymphoblastic Leukemia In the field of cancer research, understanding regulatory mechanisms of the noncoding genome remains a key focus, especially concerning how oncogenes can be aberrantly activated through non-canonical regulatory pathways. This paper, authored by Su...

Neuropilin-1 Controls Vascular Permeability through Juxtacrine Regulation of Endothelial Adherens Junctions

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
Neuropilin-1   vascular permeability   signalling   VE-cadherin   VEGFA  

Neuropilin-1 (Nrp1) is a multifunctional transmembrane protein that is abundantly expressed on the surface of various cell types, where it binds to class 3 semaphorins (Sema3), heparan sulfate, and vascular endothelial growth factors (VEGFs). Nrp1 plays a crucial role in angiogenesis and vascular permeability regulation, particularly in the VEGF si...

Genetic and Pharmacological Targeting of mTORC1 in Mouse Models of Arteriovenous Malformation Expose Non-Cell Autonomous Signalling in HHT

Medicine, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Hereditary Hemorrhagic Telangiectasia   Arteriovenous Malformation   Endothelial Cells   mTORC1   Signaling Pathways   Genetic Targeting   Pharmacological Treatment  

Genetic and Pharmacological Targeting of mTORC1 in Mouse Models of Arteriovenous Malformation Expose Non-Cell Autonomous Signalling in HHT Hereditary Hemorrhagic Telangiectasia (HHT) is a genetic disorder caused by mutations leading to the loss of function in either Activin Receptor-Like Kinase 1 (ACVRL1) or Endoglin (ENG), which act as receptors a...

Botulinum Neurotoxin Serotype A Inhibited Ocular Angiogenesis through Modulating Glial Activation via SOCS3

Medicine, Neurology, Ophthalmology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Botulinum Neurotoxin Serotype A   Choroidal Neovascularization   Age-Related Macular Degeneration   Glial Activation   Müller Activation   Microglial Activation   SOCS3  

Academic Background Age-related macular degeneration (AMD) is a major cause of central vision loss among the elderly, particularly in its neovascular (NV) form, where choroidal neovascularization (CNV) leads to rapid and severe vision loss. Current AMD treatments primarily rely on intravitreal injections of anti-vascular endothelial growth factor (...

ALK1/Endoglin Signaling Restricts Vein Cell Size Increases in Response to Hemodynamic Cues

Medicine, Cardiovascular System, Life Sciences, Cell Biology,
ALK1   Endoglin   hemodynamic cues   vein cells   arteriovenous malformations   zebrafish   hereditary hemorrhagic telangiectasia  

ALK1/Endoglin Signaling Restricts Vein Cell Size Increases in Response to Hemodynamic Cues Academic Background The normal development and function of the vascular system rely on precise regulation of blood vessel diameter. Hemodynamic cues, such as fluid shear stress (FSS), are considered critical factors in regulating vessel diameter. According to...

Oscillatory Contractile Forces Refine Endothelial Cell-Cell Interactions for Continuous Lumen Formation Governed by Heg1/CCM1

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Biophysics,
oscillatory contractile forces   endothelial cells   Heg1   CCM1   lumen formation   cell-cell interactions   angiogenesis  

Academic Background The formation and maintenance of vascular networks are critical processes in embryonic development and tissue regeneration, involving the regulation of various biophysical forces. Endothelial cells (ECs) play a central role in angiogenesis and vasculogenesis, with the contractile forces of the cytoskeleton (actomyosin contractil...