Gut Microbiota-Dependent Increase in Phenylacetic Acid Induces Endothelial Cell Senescence During Aging

Medicine, Geriatrics, Gastroenterology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Microbiology,
gut microbiota   phenylacetic acid   endothelial cell senescence   aging mechanisms   cardiovascular disease   oxidative stress  

Molecular Mechanisms of Gut Microbiota and Its Metabolites Mediating Endothelial Cell Senescence During Aging – Interpretation of Latest Results from Nature Aging I. Research Background and Significance Against the backdrop of a deeply aging human society, cardiovascular disease (CVD) has become one of the greatest health threats to the global elde...

Targeting the Chromatin Remodeler BAZ2B Mitigates Hepatic Senescence and MASH Fibrosis

Medicine, Hepatobiliary System, Geriatrics, Gastroenterology, Life Sciences, Cell Biology, Biochemistry, Genetics,
chromatin remodeling   BAZ2B   hepatic aging   MASH fibrosis   lipid metabolism   PPARα   epigenetic mechanism  

1. Research Background and Significance With global population aging on the rise, the incidence of metabolic dysfunction-associated steatohepatitis (MASH, also known as NASH) and related chronic liver diseases such as hepatic fibrosis is increasing year by year. These disorders have become a major focus and challenge in basic and clinical hepatolog...

Harnessing a Noncanonical Vestibular Input in the Head-Direction Network to Rectify Age-Related Navigational Deficits

Medicine, Basic Medical Sciences, Geriatrics, Neurology, Life Sciences, Cell Biology,
noncanonical vestibular input   head-direction network   navigation   aging   neural circuits   synaptic plasticity   cognitive decline  

Bypassing Canonical Pathways: Uncovering a “Noncanonical” Vestibular Input for Correcting Age-Related Navigational Deficits — An Analysis of “harnessing a noncanonical vestibular input in the head-direction network to rectify age-related navigational deficits” 1. Academic Background: Why Focus on Age-Related Navigational Deficits? Spatial navigatio...

Role of Recurrent Somatic Mutation and Progerin Expression in Early Vascular Aging of Chronic Kidney Disease

Medicine, Basic Medical Sciences, Geriatrics, Nephrology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Genetics,
chronic kidney disease   vascular aging   somatic mutations   progerin   vascular smooth muscle cells   clonal expansion   molecular mechanisms  

1. Academic Background and Research Rationale Chronic Kidney Disease (CKD) is a global public health challenge. Epidemiological data indicate that CKD affects approximately 10–12% of the world’s population, acting as a major driver of cardiovascular disease (CVD) mortality worldwide. CKD patients often display “Early Vascular Aging” (EVA) phenomena...

Quasi-spatial single-cell transcriptomics based on physical tissue properties defines early aging-associated niche in liver

Medicine, Hepatobiliary System, Basic Medical Sciences, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell sequencing   fibrotic niche   liver aging   senescent cells   spatial omics   physical tissue properties  

Redefining the Early-Aging Microenvironment in the Liver: Quasi-spatial Single-cell Transcriptomics Reveals Fibrotic Niche Formation and Cellular Heterogeneity Background and Research Motivation Aging is an inevitable process in life, with one of its most significant features being the accumulation of senescent cells within tissues and organs. Thes...

Single-cell and spatial transcriptomics reveal divergent microenvironments and progression signatures in early- and late-onset prostate cancer

Medicine, Basic Medical Sciences, Geriatrics, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell sequencing   spatial transcriptomics   prostate cancer   heterogeneity   tumor microenvironment   androgen response   tumor progression  

Background: Age-related Heterogeneity in Prostate Cancer and New Opportunities for Precision Medicine Prostate cancer (PCA) is the second most common malignancy and the fifth leading cause of cancer-related death among men worldwide. With the global aging population and the advancement of health screening, the age of onset for prostate cancer has b...