Exploring Diverse Approaches for Predicting Interferon-Gamma Release: Utilizing MHC Class II and Peptide Sequences

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Biochemistry, Bioengineering, Immunology,
machine learning   T-cell response   immunology   predictive modeling   interferon-gamma   MHC class II   peptide sequences  

Academic Background and Research Significance In recent decades, therapeutic proteins have gained prominence as a research focus in the biopharmaceutical industry due to their huge potential in medicine. With their high targeting ability, therapeutic protein drugs are considered to offer solutions for many acute or chronic diseases (such as certain...

Antigen Spatial-Matching Polyaptamer Nanostructure to Block Coronavirus Infection and Alleviate Inflammation

Chemistry, Nanoscience, Medicine, Infectious Diseases, Life Sciences, Bioengineering, Immunology, Microbiology,
antigen spatial matching   polyaptamer   coronavirus   inflammation   nanostructure   antiviral   anti-inflammatory  

Academic Background In recent years, multiple outbreaks caused by coronaviruses have occurred globally, such as SARS (Severe Acute Respiratory Syndrome), MERS (Middle East Respiratory Syndrome), and COVID-19 (Novel Coronavirus Pneumonia). These pandemics have not only posed a serious threat to human health but also exposed the inadequacy of emergen...

ILC2 Instructs Neural Stem and Progenitor Cells to Potentiate Neurorepair After Stroke

Medicine, Neurology, Life Sciences, Immunology,
neurorepair   ILC2   neural stem cells   stroke   neural progenitor cells   brain injury   therapeutic strategy  

Academic Background Stroke is one of the leading causes of adult disability globally, with the core issue being neuronal damage and neurological dysfunction. Although neurogenesis and neurorepair after stroke are considered crucial for recovery, the specific mechanisms remain incompletely understood. Recent studies have shown that immune cells play...

Modulation of Bone Marrow Haematopoietic Stem Cell Activity as a Therapeutic Strategy After Myocardial Infarction: A Preclinical Study

Medicine, Hematology, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
myocardial infarction   bone marrow haematopoietic stem cells   inflammation   vitamin A metabolites   cardiac function  

Academic Background Myocardial Infarction (MI) is one of the major global health concerns. Although myeloid cells in the bone marrow (BM) are crucial for tissue repair after MI, excessive myelopoiesis can exacerbate scarring and impair cardiac function. Hematopoietic stem cells (HSCs) in the bone marrow possess unique regenerative capabilities, ena...

ADSL-Generated Fumarate Binds and Inhibits STING to Promote Tumour Immune Evasion

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
tumour immune evasion   STING inhibition   ADSL   fumarate   breast cancer  

Research Background In the tumor microenvironment, highly aggressive tumors evade immune system attacks by suppressing the cGAS-STING signaling pathway. The cGAS-STING pathway is a critical mechanism for cells to sense cytoplasmic double-stranded DNA and initiate immune responses. cGAS (cyclic GMP-AMP synthase) catalyzes the production of cGAMP upo...

Discovery of Large Extracellular Vesicles Blebbisomes and Their Functional Study

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
extracellular vesicles   Blebbisomes   intercellular communication   mitochondria   immune checkpoint proteins  

Academic Background Extracellular vesicles (EVs) are crucial mediators of intercellular communication, carrying proteins, lipids, and genetic information to participate in various physiological and pathological processes. However, our understanding of EVs remains incomplete, particularly regarding the study of exceptionally large EVs. To address th...