Cellular Therapies for the Prevention and Treatment of Acute Graft-versus-Host Disease

Medicine, Rheumatology and Immunology, Hematology, Oncology, Life Sciences, Cell Biology, Immunology,
acute graft-versus-host disease   allogeneic hematopoietic cell transplantation   cellular therapy   T-cell depletion   mesenchymal stem cells   regulatory T cells   immunomodulation  

Advances in Cellular Therapies for the Prevention and Treatment of Acute Graft-versus-Host Disease (aGVHD) — An Authoritative Review on the Paper “Cellular therapies for the prevention and treatment of acute graft-versus-host disease” 1. Academic Background and Motivation Acute graft-versus-host disease (aGVHD) is one of the most severe complicatio...

Critical Role of the Potential O-Linked Glycosylation Sites of CXCR4 in Cell Migration and Bone Marrow Homing of Hematopoietic Stem Progenitor Cells

Medicine, Basic Medical Sciences, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CXCR4   O-linked glycosylation   hematopoietic stem progenitor cells   cell migration   bone marrow homing   glycosylation   CXCL12  

1. Academic Background and Research Origin Hematopoietic stem/progenitor cells (HSPCs) are the foundation for maintaining the steady state of the adult blood system. Every day, the human body needs to generate billions of new blood cells—a process that relies on the capacity of HSPCs for self-renewal and directed differentiation within the bone mar...

Inflammatory Pathways and the Bone Marrow Microenvironment in Inherited Bone Marrow Failure Syndromes

Medicine, Pediatrics, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
inherited bone marrow failure syndromes   inflammation   pro-inflammatory cytokines   bone marrow microenvironment   mesenchymal stromal cells   hematopoietic stem cells   cytokine network  

Inflammatory Pathways and Bone Marrow Microenvironment in Inherited Bone Marrow Failure Syndromes: New Insights into Chronic Inflammation Research Background and Academic Significance Inherited bone marrow failure syndromes (IBMFS) are a group of genetic disorders characterized by reduced hematopoietic cell production due to blood stem cell dysfunc...

Renal Protective Effects of Extracellular Vesicle-Encapsulated Tumor Necrosis Factor-α-Induced Protein 6 Derived from Mesenchymal Stem Cells

Medicine, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
mesenchymal stem cells   inflammation   renal protection   extracellular vesicles   TNF-α-induced protein 6   M2 macrophage polarization   regulatory T cells  

I. Research Background and Academic Significance In recent years, the incidence of acute kidney injury (AKI) has been continuously rising worldwide. AKI not only leads to acute loss of renal function but is increasingly recognized as being closely related to the occurrence and progression of chronic kidney disease (CKD). Numerous epidemiological an...

Monocytes Use Protrusive Forces to Generate Migration Paths in Viscoelastic Collagen-Based Extracellular Matrices

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Immunology, Biophysics,
monocyte   cell migration   extracellular matrix   viscoelasticity   tumor microenvironment   collagen   protrusive force  

New Mechanism of Immune Cell Migration Revealed: How Monocytes “Pioneer Their Path” in the Tumor Microenvironment I. Academic Research Background and the Central Question Cell migration is a crucial biological process in life, encompassing embryonic development, tissue repair, immune responses, and the progression of various diseases. In the contex...

Development and Validation of a Proteomic Signature of Healthspan

Medicine, Environmental and Public Health, Medical Laboratory Science, Geriatrics, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Genetics,
healthspan   proteomics   biological aging biomarkers   aging biomarkers   UK Biobank   healthy aging  

1. Academic Background: From Lifespan Extension to the Enhancement of Healthspan With the improvement of global medical and socioeconomic standards since the 20th century, overall human lifespan has significantly increased, especially in developing countries. However, healthspan—the number of years an individual lives in a state of complete health,...