Whole-Genome Analysis of Plasma Fibrinogen Reveals Population-Differentiated Genetic Regulators with Potential Liver Roles Academic Background Fibrinogen is a crucial coagulation factor and acute-phase reactive protein. Under normal physiological conditions, fibrinogen is abundant in circulation, but during the acute inflammatory response, transcri...

The Spatial Impact of a Western Diet in Enriching Galectin-1-Regulated Rho, ECM, and SASP Signaling in a Novel MASH-HCC Mouse Model Academic Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and metabolic dysfunction-associated steatohepatitis (MASH) is one of the primary triggers of HCC. With ...

Imaging-Based Factors Associated with Rapid Growth in Early-Stage Hepatocellular Carcinoma Academic Background Hepatocellular carcinoma (HCC) is the most common primary liver cancer globally and the third leading cause of cancer-related mortality, with increasing incidence and mortality rates reported in North America, South America, and Europe. Al...

Diagnostic Accuracy of CT for the Detection of Hepatic Steatosis: A Systematic Review and Meta-Analysis Academic Background Hepatic steatosis is the result of the abnormal accumulation of triglycerides in hepatocytes, which can initiate a cascade of inflammatory responses, referred to as steatotic liver disease (SLD). Metabolic dysfunction–associat...

Academic Background Liver regeneration is a complex biological process involving the coordinated action of various cell types and signaling pathways. Following partial liver resection, the remaining liver tissue restores its function and mass through a series of precisely regulated cell proliferation and immune responses. Although extensive researc...