Regulatory T Cells-Related Gene in Primary Sclerosing Cholangitis: Evidence from Mendelian Randomization and Transcriptome Data

Medicine, Hepatobiliary System, Medical Laboratory Science, Gastroenterology, Life Sciences, Immunology, Genetics,
Primary Sclerosing Cholangitis   Regulatory T Cells   Mendelian Randomization   Transcriptome Data   Machine Learning   Immune Cell Infiltration   Molecular Pathways  

Regulatory T Cells-Related Gene in Primary Sclerosing Cholangitis: Evidence from Mendelian Randomization and Transcriptome Data Authors: Jianlan Hu1, Youxing Wu1, Danxia Zhang1, Xiaoyang Wang1, Yaohui Sheng1, Hui Liao1, Yangpeng Ou2✉, Zhen Chen3, Baolian Shu1✉, and Ruohu Gui1✉ Journal: Genes & Immunity (2024) 25:492–513 DOI: https://doi.org/10.1038...

A Prognostic Molecular Signature of Hepatic Steatosis is Spatially Heterogeneous and Dynamic in Human Liver

Medicine, Hepatobiliary System, Endocrinology, Gastroenterology,
hepatic steatosis   molecular signature   spatial heterogeneity   dynamic   liver   metabolic disease   biomarkers  

Academic Background Metabolic-associated Steatotic Liver Disease (MASLD) is a major health issue affecting over 30% of the global population and is closely related to various chronic diseases such as cancer, cardiovascular disease, and renal dysfunction. The pathological spectrum of MASLD ranges from simple steatosis to steatohepatitis and progress...

Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells

Medicine, Hepatobiliary System, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Genetics,
TGF-β   signaling pathway   NK cells   hepatocellular carcinoma   iPSC   anti-tumor   immunotherapy  

Background Introduction Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with a five-year survival rate of less than 20%, and treatment options are extremely limited. Traditional targeted drug therapies, such as Sorafenib and other kinase inhibitors, have been used to treat HCC, but their efficacy is limited and diffi...

Glucagon Promotes Increased Hepatic Mitochondrial Oxidation and Pyruvate Carboxylase Flux in Humans with Fatty Liver Disease

Medicine, Hepatobiliary System, Basic Medical Sciences, Endocrinology, Gastroenterology, Life Sciences, Biochemistry,
glucagon   hepatic mitochondrial oxidation   pyruvate carboxylase   fatty liver   metabolic dysfunction  

Study on the Effect of Glucose Regulation on Hepatic Mitochondrial Oxidation and Pyruvate Carboxylase Flux in Patients with Fatty Liver Disease Research Background and Significance Metabolic-dysfunction-associated Steatotic Liver Disease (MASLD) has become one of the major challenges in global health in the 21st century. This condition is often acc...

Amino Acid is a Major Carbon Source for Hepatic Lipogenesis

Medicine, Hepatobiliary System, Gastroenterology, Life Sciences, Biochemistry,
liver   lipogenesis   amino acids   metabolic dysfunction   nutrient intake   low-protein diet   obesity  

Research Report on the Relationship Between High Protein Diet and Liver Fat Synthesis Background and Significance Globally, the prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is gradually increasing, becoming a common issue among people with obesity and insulin resistance. The pathological development of this disease...