Treadmill Exercise Reshapes Cortical Astrocytic and Neuronal Activity to Improve Motor Learning Deficits Under Chronic Alcohol Exposure

Background and Research Motivation Alcohol abuse is a global health issue, affecting over 8% of the male population. Prolonged alcohol exposure can alter the homeostasis of neurons and synapses in the brain, leading to various mental disorders and cognitive deficits, especially in motor learning. Previous studies have shown that alcohol abuse cause...

Predictable Navigation through Spontaneous Brain States with Cognitive-Map-Like Representations

Predictable Navigation through Spontaneous Brain States with Cognitive-Map-Like Representations

Advances in Neurobiology: “Navigating” Predictable Spontaneous Brain States through Cognitive Maps Background Introduction Spontaneous brain activity refers to brain processes that are not constrained by specific inputs or outputs, and these processes play an important role in neural and cognitive variability. Although the specific mechanisms of sp...

Phase of Neural Oscillations as a Reference Frame for Attention-Based Routing in Visual Cortex

Phase of Neural Oscillations as a Reference Frame for Attention-Based Routing in Visual Cortex

One of the key issues in understanding the visual system’s selective attention is how it optimizes the perception and processing of visual information in specific behavioral contexts. Although previous research has analyzed the pivotal role of individual neuron firing rates in information transmission, our understanding remains limited regarding ho...

Accumulation of NMDA Receptors in Accumbal Neuronal Ensembles Mediates Increased Conditioned Place Preference for Cocaine After Prolonged Withdrawal

Study Reveals Molecular Mechanisms of Enhanced Cocaine Craving in Rats During Withdrawal Background Introduction The issue of relapse in drug abuse poses a significant challenge in addiction treatment. According to related research, relapse behaviors in drug addiction are often triggered by environmental cues associated with drug use. This phenomen...

Central C3a Receptor Modulates LPS-Induced Depressive-like Behaviors

The Regulatory Mechanism of Central Complement C3a Receptor on LPS-Induced Depressive-Like Behavior Introduction With the increasing number of depression patients globally, major depressive disorder (MDD) has become one of the leading causes of disability worldwide. The symptoms, treatment effects, and biological correlations of depression exhibit ...