Predictive Pharmacodynamic Performance of the Eleveld Pharmacokinetic-Pharmacodynamic Model for Propofol: Comparison of Predicted and Measured Bispectral Index

Medicine, Anesthesiology,
Propofol   Pharmacokinetics   Pharmacodynamics   Bispectral Index   Intravenous Anaesthesia   Computer Simulation   Prediction Error  

In the field of anesthesiology, propofol is a widely used intravenous anesthetic, and its pharmacokinetic (PK) and pharmacodynamic (PD) models are crucial for precise control of anesthetic depth. The Eleveld model is a widely applied PK-PD model for propofol, capable of predicting propofol plasma concentrations, effect-site concentrations, and the ...

Effects of Inhalation versus Total Intravenous Anaesthesia on Long-Term Mortality in Older Patients after Noncardiac Surgery: A Retrospective Observational Study

Medicine, Anesthesiology,
geriatrics   noncardiac surgery   inhalation anaesthesia   intravenous anaesthesia   long-term mortality   postoperative complications   retrospective study  

Effects of Inhalation versus Total Intravenous Anaesthesia on Long-Term Mortality in Older Patients after Noncardiac Surgery: A Retrospective Observational Study Academic Background With the global aging phenomenon, the number of elderly patients undergoing surgery is increasing year by year. Elderly patients are more susceptible to adverse effects...

Distribution and Outcomes of Paediatric Anaesthesia Services in Sweden: An Epidemiological Study

Medicine, Pediatrics, Anesthesiology,
paediatric anaesthesia   epidemiology   Sweden   complications   mortality   centralisation   neonates  

Distribution and Outcomes of Paediatric Anaesthesia Services in Sweden: An Epidemiological Study Academic Background In recent years, there has been a growing trend towards the centralization of perioperative care for children globally, particularly in European countries. This trend is primarily driven by research findings from professional organiz...

Dopaminergic Psychostimulants Cause Arousal from Isoflurane-Induced Sedation Without Reversing Memory Impairment in Rats

Medicine, Anesthesiology,
memory impairment   arousal   dopamine   isoflurane   psychostimulant   sedation   rat model  

Dopaminergic Psychostimulants Restore Arousal from Isoflurane-Induced Sedation Without Reversing Memory Impairment in Rats Academic Background The widespread use of anesthetic drugs in surgery allows patients to undergo treatment without pain. However, the impact of anesthetic drugs on memory has been a significant research topic in the field of an...

Effect of a Comfort Scale Compared with a Pain Numerical Rate Scale on Opioids Consumption in Postanaesthesia Care Unit: The COMFORT Study

Medicine, Anesthesiology,
comfort scale   pain assessment   postoperative analgesia   opioids   postanaesthesia care unit   randomised trial   postoperative pain  

The Effect of a Comfort Scale Compared with a Pain Numerical Rating Scale on Opioid Consumption in the Post-Anaesthesia Care Unit: The COMFORT Study Academic Background Postoperative pain management is a critical topic in anaesthesiology and intensive care medicine. Effective pain assessment tools can help physicians optimize postoperative analgesi...

Family Supplemented Patient Monitoring After Surgery (SMARTER): A Pilot Stepped-Wedge Cluster-Randomised Trial

Medicine, Obstetrics and Gynecology, Nursing, Anesthesiology,
postoperative monitoring   family involvement   stepped-wedge trial   Africa   surgical mortality   patient safety   task sharing  

Academic Background In Africa, postoperative mortality is twice that of high-income countries, with most deaths occurring on hospital wards after patients develop postoperative complications. The primary reason for this is inadequate postoperative monitoring, leading to delayed recognition and intervention when patients deteriorate. In Africa, heal...