Reduced Oxycodone Brain Delivery in Rats due to Lipopolysaccharide-Induced Inflammation: Microdialysis Insights into Brain Disposition and Sex-Specific Pharmacokinetics

Medicine, Anesthesiology, Pharmacy,
blood-brain barrier   oxycodone   microdialysis   sex-specific   lipopolysaccharides   inflammation   pharmacokinetics  

The Impact of Inflammation on Brain Delivery of Oxycodone Academic Background Oxycodone is a widely used opioid analgesic with a unique property of being actively transported from the blood to the brain across the blood-brain barrier (BBB). This process is believed to be associated with the proton-coupled organic cation (H+/OC) antiporter system. H...

Regulation of Calcium Homeostasis in Endoplasmic Reticulum–Mitochondria Crosstalk: Implications for Skeletal Muscle Atrophy

Medicine, Anesthesiology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Biophysics,
skeletal muscle   calcium   atrophy   mitochondria   endoplasmic reticulum   calcium homeostasis   muscle diseases  

The Critical Role of Calcium in Skeletal Muscle Function and Its Interaction with Mitochondria and the Endoplasmic Reticulum Academic Background Calcium ions (Ca²⁺) are crucial intracellular signaling molecules, particularly in the excitation-contraction coupling (ECC) of skeletal muscle. The contraction of skeletal muscle relies on the release and...

Repeated Postnatal Sevoflurane Exposure Impairs Social Recognition in Mice by Disrupting GABAergic Neuronal Activity and Development in Hippocampus

Medicine, Anesthesiology, Neurology,
anaesthetic neurotoxicity   GABAergic neurone   hippocampus   sevoflurane   social interaction  

Repeated Exposure to Sevoflurane Impairs GABAergic Neuronal Development and Social Cognitive Function in the Hippocampal CA2 Region of Mice Academic Background Approximately 1.5 million infants and young children undergo medical procedures requiring general anesthesia annually, with sevoflurane being widely used in pediatric anesthesia. However, in...

Personalised Perioperative Dosing of Ivabradine in Noncardiac Surgery: A Single-Centre, Randomised, Placebo-Controlled, Double-Blind Feasibility Pilot Trial

Medicine, Anesthesiology, Cardiovascular System,
perioperative   ivabradine   noncardiac surgery   myocardial injury   feasibility study  

Personalized Perioperative Dosing of Ivabradine in Noncardiac Surgery: A Single-Centre, Randomised, Placebo-Controlled, Double-Blind Feasibility Pilot Trial Academic Background Perioperative myocardial injury (PMI) is a common complication following noncardiac surgery and is closely associated with postoperative mortality and morbidity. Studies hav...

The Lifetime Risk of Surgery in England: A Nationwide Observational Cohort Study

Medicine, Obstetrics and Gynecology, Anesthesiology,
lifetime risk   surgery   COVID-19   epidemiology   public health   resource planning   cohort study  

Lifetime Risk of Surgery in England: A Nationwide Observational Cohort Study Academic Background Surgery represents a significant portion of the UK National Health Service (NHS) activity, with approximately 4.4 million people undergoing surgical procedures in England each year. Although an increasing number of surgeries are performed as day-case pr...

Predictive Pharmacodynamic Performance of the Eleveld Pharmacokinetic-Pharmacodynamic Model for Propofol: Comparison of Predicted and Measured Bispectral Index

Medicine, Anesthesiology,
Propofol   Pharmacokinetics   Pharmacodynamics   Bispectral Index   Intravenous Anaesthesia   Computer Simulation   Prediction Error  

In the field of anesthesiology, propofol is a widely used intravenous anesthetic, and its pharmacokinetic (PK) and pharmacodynamic (PD) models are crucial for precise control of anesthetic depth. The Eleveld model is a widely applied PK-PD model for propofol, capable of predicting propofol plasma concentrations, effect-site concentrations, and the ...