Differential Cortical Layer Engagement During Seizure Initiation and Spread in Humans

Differential Cortical Layer Engagement During Seizure Initiation and Spread in Humans

Study on the Differences in Cortical Layers During Epileptic Seizure Onset and Spread Epilepsy is a neurological disorder that severely impacts patients’ quality of life, affecting approximately 1% of the global population. Among all epilepsy patients, nearly one-third are resistant to pharmaceutical treatments, known as drug-resistant epilepsy. Fo...

Consensus on Pediatric Epilepsy Surgery for Young Children

Consensus Study Report on Pediatric Epilepsy Surgery Background Introduction The incidence of epilepsy varies significantly across different age groups. According to the International League Against Epilepsy (ILAE), the highest incidence rates of epilepsy are found among those under 5 years old and over 65 years old (>60 per 100,000 people), with c...

Yield of Non-Invasive Imaging in MRI-Negative Focal Epilepsy

Clinical Utility of Non-invasive Imaging in MRI-negative Focal Epilepsy Academic Background Epilepsy surgery is a crucial treatment modality for drug-resistant epilepsy. However, the likelihood of achieving good outcomes postoperatively is significantly diminished when Magnetic Resonance Imaging (MRI) fails to detect lesions. Previous studies indic...

Neurophysiological Study of Orientation Discrimination in a Working Memory Task

Neurophysiological Study: Neurophysiological Research on Orientation Discrimination in a Working Memory Task Background Recognizing and remembering the spatial orientation of the environment is a crucial component of visuospatial behavior. Accurately storing and recalling this information helps us navigate in space and respond adaptively to rapid c...

Theta Oscillations Support Prefrontal-Hippocampal Interactions in Sequential Working Memory

Study on Theta Oscillations in Hippocampus-Prefrontal Interaction Supporting Sequential Working Memory Academic Background The dorsolateral prefrontal cortex (DLPFC) and the hippocampus play crucial roles in sequential working memory, but the specific interaction mechanisms are not yet clear. Previous studies have shown that these two brain regions...